Autonomic dysfunction in childhood hypersomnia disorders

Jagadish, Spoorthi; Singer, Wolfgang; Kotagal, Suresh

doi:10.1016/j.sleep.2020.11.040

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…77 Autonomic dysfunction has been described in narcolepsy in several studies, and has been put forward as a possible mechanism leading to fatigue as well. [78][79][80][81] Importantly, a presenting complaint of fatigue should always prompt to probe whether sleepiness is present, and a prominent fatigue complaint does not rule out narcolepsy.…”

Section: Fatiguementioning

confidence: 99%

Recognizing the Symptom Spectrum of Narcolepsy to Improve Timely Diagnosis: A Narrative Review

Quaedackers¹,

Pillen²,

Overeem³

2021

NSS

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Narcolepsy is a chronic sleep disorder with a strong negative impact on quality of life, especially when untreated. Diagnostic delay is a persistent problem, with obvious detrimental effects on patients. A diagnosis of narcolepsy may be delayed because of its broad symptom presentation which is much more encompassing than the classical "tetrad" of sleepiness, cataplexy, hallucinations, and sleep paralysis. Furthermore, symptoms can vary over time. Presentation of symptoms can also be markedly different between children and adults. Finally, common sleep-related comorbidities increase the risk of narcolepsy being masked by overlapping symptoms or treatment. In this review, we provide a detailed description of the broad and dynamic symptom spectrum of narcolepsy, with specific attention to the different manifestations in both adults and children. The overarching goal is to help not only sleep specialists, but general practitioners, pediatricians, and other caregivers with early recognition and prompt diagnosis of this severe but treatable disorder.

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Section: Fatiguementioning

confidence: 99%

Recognizing the Symptom Spectrum of Narcolepsy to Improve Timely Diagnosis: A Narrative Review

Quaedackers¹,

Pillen²,

Overeem³

2021

NSS

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“…Eleven of the 33 had IH while the rest had either narcolepsy, secondary hypersomnia or periodic hypersomnia. 12…”

Section: Ih and Autonomic Dysfunctionmentioning

confidence: 99%

Autonomic dysfunction in idiopathic hypersomnia: an overlooked association and potential management

Adra

Reddy

Attarian

et al. 2022

Journal of Clinical Sleep Medicine

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Journal of Clinical Sleep Medicine is dedicated to advancing the science of clinical sleep medicine. In order to provide subscribers with access to new scientific developments as early as possible, accepted papers are posted prior to their final publication in an issue.These papers are posted as received-without copyediting or formatting by the publisher. In some instances, substantial changes are made during the copyediting and formatting processes; therefore, the final version of the paper may differ significantly from this version.

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“…Here, we review the autonomic disorders and their possible mechanisms in patients with NT1 (Figure 1). Previous studies suggested that 52% of adults with NT1 and 37% of children with NT1 and other hypersomnia disorders had the symptoms of orthostatic intolerance, indicating impairment of cardiovascular autonomic regulation (5,6). Autonomic disorders in the cardiovascular system may increase the risk of cardiovascular events and reduce the quality of life of patients with NT1.…”

Section: Introductionmentioning

confidence: 99%

Progress of autonomic disturbances in narcolepsy type 1

Wang

Sun²,

Tang³

et al. 2023

Front. Neurol.

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Narcolepsy type 1 is a kind of sleep disorder characterized by a specific loss of hypocretin neurons in the lateral hypothalamus and reduced levels of hypocretin-1 in the cerebrospinal fluid. Hypocretin deficiency is associated with autonomic disorders. This article summarizes the autonomic disorders and possible mechanisms associated with narcolepsy type 1. Patients with narcolepsy type 1 often have various systemic autonomic symptoms, including non-dipping blood pressure, reduced heart rate variability, dynamic cerebral autoregulation impairment, reduced gastric motility and emptying, sleep-related erectile dysfunction, skin temperature abnormalities, and blunted pupillary light reflex. Similar findings should strengthen the recognition and intervention of these disturbances in clinical practice. In addition to hypocretin deficiency, current evidence also indicates that pharmacological therapy (including psychostimulants and anti-cataplectic drugs) and comorbidities may contribute to the alterations of autonomic system observed in narcolepsy type 1.

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Autonomic dysfunction in childhood hypersomnia disorders

Cited by 8 publications

References 17 publications

Recognizing the Symptom Spectrum of Narcolepsy to Improve Timely Diagnosis: A Narrative Review

Recognizing the Symptom Spectrum of Narcolepsy to Improve Timely Diagnosis: A Narrative Review

Autonomic dysfunction in idiopathic hypersomnia: an overlooked association and potential management

Progress of autonomic disturbances in narcolepsy type 1

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