Autonomic involvement in idiopathic premature ventricular contractions

Abstract

HR dependency reflected autonomic modulation of idiopathic PVCs. F-PVC and S-PVC might be facilitated by sympathetic activation and vagal activation, respectively. HR dependency and the related autonomic mechanisms should be considered when treating idiopathic PVCs.

Assessment of a novel transdermal selective β1-blocker, the bisoprolol patch, for treating frequent premature ventricular contractions in patients without structural heart disease

“…The difference in the degree of night-time PVC suppression between the P-PVC and NP-PVC groups may have contributed to a significant mean night-time HR reduction in the P-PVC group compared to the NP-PVC group. There was no significant difference observed in the change in the mean day-time HR (p = 0.28) from baseline, however, a trend was observed in that the degree of the change in the mean day-time HR was larger in the [8]. In this study, the bisoprolol patch did not change the PVC count significantly (p = 0.080) in patients with negative HR-dependent PVCs.…”

“…PVCs were divided into two types based on their HR dependency, which was evaluated by the relationships between the hourly PVC density and hourly mean HR measured by 24-hour Holter ECGs. The methods were fundamentally the same as those reported by He et al [8]. Then their relationship was analyzed by a Pearson's correlation.…”

“…He et al demonstrated that there are different relationships between the PVC density and HR in idiopathic PVCs, and that PVCs with their density positively related to the HR might be facilitated by sympathetic activation, PVCs with their density negatively related to the HR might be facilitated by the parasympathetic activation, and when no evident relationship between the PVC density and HR exists, those PVCs might have an independent autonomic mechanism [8]. We analyzed the relationship between the hourly PVC density and hourly mean HR to estimate the HR dependency of PVCs following this method, and investigated the efficacy of the bisoprolol patch on decreasing the frequency of PVCs in patients without SHD by considering the HR dependency and related autonomic mechanism.…”

“…In most cases, sympathetic activation could trigger the occurrence of idiopathic PVCs, but a few studies showed ventricular arrhythmias (VAs) develop when parasympathetic activation is increased in some patients [7]. He et al suggested that the heart rate (HR) dependency of idiopathic PVCs revealed different autonomic mechanisms [8]. b-Blockers might have provided insufficient suppression of idiopathic PVCs due to the presence of PVCs not facilitated by sympathetic activation.…”

Ambient fine particulate matter (PM2.5) exposure is associated with idiopathic ventricular premature complexes burden: A cohort study with consecutive Holter recordings

“…The incidence of VPCs has a diurnal pattern, with fewer VPCs occurring during sleep and more during waking hours. 24 He et al 25 demonstrated the heart rate dependency of idiopathic VPCs by comparing HRV parameters and VPC density. previous HRV studies showed that PM2.5 exposures affect the autonomic system.…”