Autonomic regulation of hematopoiesis and cancer

Toro, R.; Méndez-Ferrer, Simón

doi:10.3324/haematol.2013.084764

Cited by 25 publications

(21 citation statements)

References 38 publications

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“…Moreover, the sympathetic tone regulates leukocyte abundance and distribution, presumably to provide anticipatory immunity during periods of peak activity when individuals are at a greater risk for pathogen exposure [111–113]. Sympathetic nerves transmitting circadian cues from the CNS entrain circadian rhythmicity on tissues by connecting the central clock of the suprachiamsatic nucleus with the peripheral clock in each tissue [114]. This has functional effects on leukocyte numbers in the circulation and in tissues by regulating levels of endothelial adhesion molecules, such as ICAM-1 in skeletal muscle and P- and E-selectin in the BM [113] (Figure 2).…”

Section: Role Of the Pns In The Development Deployment And Homeostamentioning

confidence: 99%

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

Ordovás-Montañés

Rakoff-Nahoum

Huang

et al. 2015

Trends in Immunology

149

123

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The nervous system and the immune system are the principal sensory interfaces between the internal and external environment. They are responsible for recognizing, integrating, and responding to varied stimuli, and have the capacity to form memories of these encounters leading to learned or ‘adaptive’ future responses. Here, we review the current understanding of the cross-regulation between these systems. The autonomic and somatosensory nervous systems regulate both the development and deployment of immune cells, with broad functions that impact hematopoiesis as well as priming, migration and cytokine production. In turn, specific immune cell subsets contribute to homeostatic neural circuits such as those controlling metabolism, hypertension and the inflammatory reflex. We examine the contribution of the somatosensory system to autoimmune, autoinflammatory, allergic, and infectious processes in barrier tissues and in this context, discuss opportunities for therapeutic manipulation of neuro-immune interactions.

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Section: Role Of the Pns In The Development Deployment And Homeostamentioning

confidence: 99%

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

Ordovás-Montañés

Rakoff-Nahoum

Huang

et al. 2015

Trends in Immunology

149

123

View full text Add to dashboard Cite

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“…However, recent results suggest that the process could be more complex and the effects of innervation would vary rhythmically and affect different processes in the BM. Systemic activation of β adrenergic receptors does not increase circulating haematopoietic progenitors unless HSC homing is also blocked [97] suggesting that adrenergic stimulation might not only affect mobilization but also homing of haematopoietic progenitors in the BM and/or peripheral tissues [102]. Indeed, when mice defective in E-and P-selectins showing additional α4 integrin blockade, which inhibited the homing to BM, received isoproterenol, an adrenergic antagonist, during the morning phase they showed considerable HSC mobilization.…”

Section: Adult Stem Cell Nichesmentioning

confidence: 99%

“…This possibility was discarded because adrenergic receptors involved in these processes were largely β3 receptors not expressed on osteoblasts but on CAR cells and nestin-expressing perivascular cells [33,52]. Presumably, both adrenergic receptors contribute to regulate haematopoiesis in BM [102].…”

Section: Adult Stem Cell Nichesmentioning

confidence: 99%

The Adult Hematopoietic Niches — Cellular Composition, Histological Organization and Physiological Regulation

Zapata¹

2014

Adult Stem Cell Niches

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“…38 Over the past six decades, a number of b 2 AR ligands have been identified on the basis of ligand analogue. In fact, G protein-coupled receptors are among the most frequent targets for a number of drugs and several of them target b 2 AR.…”

Section: Fig 8 (A)mentioning

confidence: 99%

Todralazine Protects Zebrafish from Lethal Effects of Ionizing Radiation: Role of Hematopoietic Cell Expansion

et al. 2015

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The Johns Hopkins Clinical Compound Library ( JHCCL), a collection of Food and Drug Administration (FDA)-approved small molecules (1400), was screened in silico for identification of novel b 2 AR blockers and tested for hematopoietic stem cell (HSC) expansion and radioprotection in zebrafish embryos. Docking studies, followed by the capacity to hasten erythropoiesis, identified todralazine (Binding energy, -8.4 kcal/mol) as a potential HSC-modulating agent. Todralazine (5 lM) significantly increased erythropoiesis in caudal hematopoietic tissue (CHT) in wild-type and anemic zebrafish embryos (2.33-and 1.44-folds, respectively) when compared with untreated and anemic control groups. Todralazine (5 lM) treatment also led to an increased number of erythroid progenitors, as revealed from the increased expression of erythroid progenitor-specific genes in the CHT region. Consistent with these effects, zebrafish embryos, Tg(cmyb:gfp), treated with 5 lM todralazine from 24 to 36 hours post fertilization (hpf) showed increased (approximately two-folds) number of HSCs at the aorta-gonad-mesonephros region (AGM). Similarly, expression of HSC marker genes, runx1 (3.3-folds), and cMyb (1.41-folds) also increased in case of todralazine-treated embryos, further supporting its HSC expansion potential. Metoprolol, a known beta blocker, also induced HSC expansion (1.36-and 1.48-fold increase in runx1 and cMyb, respectively). Todralazine (5 lM) when added 30 min before 20 Gy gamma radiation, protected zebrafish from radiation-induced organ toxicity, apoptosis, and improved survival (80% survival advantage over 6 days). The 2-deoxyribose degradation test further suggested hydroxyl (OH) radical scavenging potential of todralazine, and the same is recapitulated in vivo. These results suggest that todralazine is a potential HSC expanding agent, which might be acting along with important functions, such as antioxidant and free radical scavenging, in manifesting radioprotection.

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Autonomic regulation of hematopoiesis and cancer

Cited by 25 publications

References 38 publications

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

The Adult Hematopoietic Niches — Cellular Composition, Histological Organization and Physiological Regulation

Todralazine Protects Zebrafish from Lethal Effects of Ionizing Radiation: Role of Hematopoietic Cell Expansion

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