Autonomic responses to lateralized cold pressor and facial cooling tasks

McGinley, Jared J.; Friedman, Bruce H.

doi:10.1111/psyp.12332

Cited by 27 publications

(19 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After a ten-minute rest, women participated in the CPT to assess pain sensitivity and HPA axis function. The CPT is one of the most frequently used procedures to measure pain sensitivity in a laboratory setting (Koenig et al, 2014; McGinley & Friedman, 2015). Participants submerge their hand in ice water, eliciting a strong sympathetic nervous system stress response and activation of the HPA axis.…”

Section: Methodsmentioning

confidence: 99%

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Lara-Cinisomo

Grewen

Girdler

et al. 2017

Women's Health Issues

View full text Add to dashboard Cite

Background Latinas are disproportionately affected by perinatal depression (PND) as well as by adverse life events (ALEs), an independent predictor of PND. Dysregulation of the hypothalamic-adrenal-pituitary (HPA) axis has been seen both in women with PND and with a history of ALEs in non-Latinas. Though some evidence suggests that HPA axis dysregulation may mediate the link between ALEs and PND, this has received little attention and there are no studies that have examined these pathways in Latinas. The primary aim of the present study was to explore, in a Latina sample, associations between ALEs, PND, and HPA axis stress reactivity to a physical stressor-the cold pressor test (CPT). The secondary aim was to explore whether HPA axis reactivity and PND were associated with pain sensitivity to the CPT. Methods Thirty-four Latinas were enrolled in their third trimester of pregnancy and interviewed at 4 and 8 weeks postpartum. Depression status was determined using the Edinburgh Postnatal Depression Scale (≥ 10). At 8 weeks postpartum, 27 women underwent laboratory-induced pain testing using the cold pressor test (CPT). Plasma adrenocorticotropic hormone (ACTH) and cortisol (CORT) were sampled pre- and post-CPT to generate a stress reactivity score (post-pre). Pain sensitivity and ALEs were also assessed. Results At enrollment, 26% of women were depressed and 18% were depressed at 8 weeks postpartum. Forty-eight percent reported at least one childhood ALE. There was a significant and positive association between any childhood ALE and prenatal depression scores (p = 0.025). Infant-related ALEs were significantly associated with greater ACTH reactivity to the CPT (p = 0.030). Women with a history of any childhood ALE exhibited a blunted CORT response to the CPT (p = 0.045). Women with a history of PND at 4 weeks had greater ACTH stress reactivity to the CPT (p = 0.027). No significant effects of PND were seen for pain sensitivity measures in response to the CPT, though there was a positive and significant correlation between pain tolerance and CORT response to the CPT in the whole sample. Conclusions Given the associations between ALEs and PND and their individual effect on HPA axis stress reactivity, future studies on perinatal depression should include a larger sample of Latinas to test mediating effects of HPA axis reactivity on associations between ALEs and PND.

show abstract

Section: Methodsmentioning

confidence: 99%

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Lara-Cinisomo

Grewen

Girdler

et al. 2017

Women's Health Issues

View full text Add to dashboard Cite

show abstract

“…However, these advantages are opposed by some practical disadvantages due to the typical unilateral hand immersion. As such, unilateral CPT's induces laterality specific effects (Harper et al, 2000;McGinley & Friedman, 2015) that may create unwanted interference in all studies that require unilateral stimulus presentation or lateralized responses (e.g. somatic motor activation) in some form.…”

Section: Introductionmentioning

confidence: 99%

Enhanced stress response by a bilateral feet compared to a unilateral hand Cold Pressor Test

Larra

Schilling

Röhrig

et al. 2015

Stress

View full text Add to dashboard Cite

The Cold Pressor Test (CPT) is a frequently employed laboratory stress protocol. However, with many experimental designs the application in its classic form (immersion of the dominant hand into ice-water) is problematic as unilateral stimulation may need to be avoided and/or hands are required for further measurements. Here, we describe a simple modification of the classic CPT in which both feet are immersed into ice-water and compare the evoked neuroendocrine stress response to the classic CPT in a within-subjects design. Twenty-four healthy participants were exposed to each of both CPT versions on two subsequent days in randomized order. Heart rate, blood pressure, salivary alpha-amylase and cortisol were measured at baseline and during or after CPT exposition, respectively, along with subjective ratings of pain and stress. The bilateral feet CPT induced marked increases in all measured stress parameters. Moreover, with the exception of blood pressure, autonomic and endocrine responses were enhanced compared to the classic CPT. The bilateral feet CPT thus is a valid and simple modification and may be useful when the application of the classic CPT is unfeasible or a stronger neuroendocrine stress response is of interest.

show abstract

“…In this study, we test the ability of combined HRV and EDA measures in characterizing sympathovagal balance. Specifically, we study the ratio between EDA Symp from EDA vs. HF power from HRV in a gold-standard experiment evoking sympathetic activation known as the cold-pressor test (CPT) [7]. In fact, non-baroreflex-mediated sympathetic neural control in humans has been evaluated using CPT in both clinical and experimental settings [8]- [10].…”

Section: Introductionmentioning

confidence: 99%

A New Sympathovagal Balance Index from Electrodermal Activity and Instantaneous Vagal Dynamics: A Preliminary Cold Pressor Study

Ghiasi¹,

Grecol²,

Nardelli³

et al. 2018

2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

View full text Add to dashboard Cite

Sympathovagal balance, an autonomic index resulting from the sympathetic and parasympathetic influences on cardiovascular control, has been extensively used in the research practice. The current assessment is based on analyzing Heart Rate Variability (HRV) series in the frequency domain by regarding the ratio between the low and high frequency components (LF/HF). Nevertheless, LF and HF powers are known to be both influenced by vagal activity which strongly bias the accuracy of this method. To this extent, in this study we combine time-varying estimates from electrodermal activity (EDA) and HRV to propose a novel index of sympathovagal balance. Particularly, sympathetic activity is estimated from the EDA power calculated within the 0.045-0.25Hz bandwidth (EDASymp), whereas parasympathetic dynamics is measured instantaneously through a point-process modeling framework devised for heartbeat dynamics (HFpp). We test our new index S = EDASymp/HFpp on data from 22 healthy subjects (7 females and 15 males) undergoing a 3 minutes gold-standard protocol for sympathetic elicitation as the cold-pressor test (CPT). Results show that the activation of the proposed sympathovagal tone is consistent with CPT elicitation and is associated with a significantly higher statistical discriminant power than the standard LF/HF ratio, also revealing different dynamics between female and male subjects.

show abstract

Autonomic responses to lateralized cold pressor and facial cooling tasks

Cited by 27 publications

References 71 publications

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Enhanced stress response by a bilateral feet compared to a unilateral hand Cold Pressor Test

A New Sympathovagal Balance Index from Electrodermal Activity and Instantaneous Vagal Dynamics: A Preliminary Cold Pressor Study

Contact Info

Product

Resources

About