Autonomous Microcapillary Drug Delivery System Self‐Powered by a Flexible Energy Harvester

Gabrielsson, Erik O.; Jung, Young-Hoon; Han, Jae Hyun; Joe, Daniel J.; Simon, Daniel T.; Lee, Keon Jae; Berggren, Magnus

doi:10.1002/admt.202100526

Cited by 11 publications

(3 citation statements)

References 45 publications

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“…Generation of Cation-Delivery OEIPs: Silica capillaries (25/125 µm inner/outer diameter, Molex TSP025150) were used and fabricated by a protocol previously reported. [53,54] The 12.5 µm protective polyimide coating of the capillaries was removed by immersion in a hot bath (120 °C) of concentrated sulfuric acid, and the resulting capillaries were thoroughly rinsed in Di water. Subsequently, 20 cm sections of each capillary were cut and flushed with H 2 O by using dry nitrogen (5 bar).…”

Section: Methodsmentioning

confidence: 99%

iP & OEIP – Cytokinin Micro Application Modulates Root Development with High Spatial Resolution

Pařízková

Antoniadi

Poxson

et al. 2022

Adv Materials Technologies

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which potentially allows electronic control of their local concentrations by precise hormone delivery. Organic electronic ion pumps (OEIPs) are a novel technology that enables the highly controlled transport of various organic substances with unprecedented spatial and temporal resolution. [1] Ions are transported from a pump reservoir to a target matrix through a delivery channel carrying ion (cation/anion) exchange membranes (IEMs) with a high density of fixed charged groups. Flow-free and highly selective transport of the ions is achieved by the application of a controlled electric current, resulting in a steep concentration gradient at the delivery channel outlet. In addition, simple manipulation of the electrical parameters (voltage/current) can precisely fine-tune the amounts of molecules delivered to the target tissue. [1] The OEIP approach was primarily developed for biomedical applications for precise delivery of small neurosignaling inorganic ions, such as K + , Na + , Cl − , and Ca 2+ , [2] and smaller organic compounds, such as γ-aminobutyric acid (GABA), [3,4] glutamate (Glu) [3] and acetylcholine (ACh). [5][6][7] Further optimization of IEM materials has resulted in the development of hyperbranched membranes (dendrolytes) enabling the transport of larger aromatic substances, such as the plant hormones indole-3-acetic acid (IAA) [8] or abscisic acid (ABA). [9] State-of-the-art technology based on organic electronics can be used as a flow-free delivery method for organic substances with high spatial resolution. Such highly targeted drug micro applications can be used in plant research for the regulation of physiological processes on tissue and cellular levels. Here, for the first time, an organic electronic ion pump (OEIP) is reported that can transport an isoprenoid-type cytokinin, N 6 -isopentenyladenine (iP), to intact plants. Cytokinins (CKs) are plant hormones involved in many essential physiological processes, including primary root (PR) and lateral root (LR) development. Using the Arabidopsis thaliana root as a model system, efficient iP delivery is demonstrated with a biological output -cytokinin-related PR and LR growth inhibition. The spatial resolution of iP delivery, defined for the first time for an organic compound, is shown to be less than 1 mm, exclusively affecting the OEIP-targeted LR. Results from the application of the high-resolution OIEP treatment method confirm previously published findings showing that the influence of CKs may vary at different stages of LR development. Thus, OEIP-based technologies offer a novel, electronically controlled method for phytohormone delivery that could contribute to unraveling cytokinin functions during different developmental processes with high specificity.

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Section: Methodsmentioning

confidence: 99%

iP & OEIP – Cytokinin Micro Application Modulates Root Development with High Spatial Resolution

Pařízková

Antoniadi

Poxson

et al. 2022

Adv Materials Technologies

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“…Figure 4 shows the possible applications of PEH for implantable medical devices. The various applications of the PEH for IMDs are drug delivery (Gabrielsson et al, 2021), pacemaker (Kabir et al, 2022), dental implant (Park et al, 2020), in vivo diagnosis & treatment (Zhang et al, 2022b), cancer Therapy (Truong Hoang et al, 2023), repair of nerve tissue (Wu et al, 2022), neuro regulation (Guan et al, 2023), acoustic transmitter (Jiang et al, 2022), bariatric (Dagdeviren et al, 2017), cochlear implant (İlik et al, 2018), knee implant (Safaei et al, 2018) and myriad (Sun et al, 2019) to quote a few.…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in piezoelectric energy harvesting for implantable medical devices

Upendra,

Panigrahi,

Singh

et al. 2023

Journal of Intelligent Material Systems and Structures

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Biomedical implantable devices like deep brain stimulators, implantable cardioverter-defibrillators and cardiac pacemakers are essential for treating the human heart and brain-related diseases. In the past few decades, a considerable amount of research has focused on improving bio-implant technologies. Conventional bio implant devices consist of an external generator like a battery to power the system, which requires replacement after a particular time. Therefore, in recent years, self-powered implants with various energy harvesting techniques have been proposed to avoid frequent surgery for battery replacement and to miniaturise the implant systems. However, the research communities have yet to explore all the limitations and possibilities of improvement on such energy-scavenging technologies, especially when the application is in vivo. Several aspects of recent developments in energy harvesting technologies feasible for biomedical implantable devices are reported systematically. A detailed review of piezoelectric energy harvester mechanism and miniaturisation, electric output and power management and biocompatibility of an energy harvester for implantable medical devices in vitro and in vivo environments. Furthermore, the piezoelectric energy harvester’s durability, packaging material, connection and evaluation criteria are discussed.

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“…Until recently, several methods have been proposed in order to obtain the flexible ferroelectric thin film, and they have been widely used commercially [20]; such methods include growing thin film on flexible polymer substrates [21], etching onto rigid substrates [22,23], and the "grow-transfer" method [24][25][26][27]. The "grow-transfer" method is considered promising because it protects the excellent piezoelectric performance and it guarantees the flexibility and integrity of the films by using physical [28][29][30] (e.g., laser lift-off) or chemical [31][32][33] (e.g., wet etching) routes to separate the film from the rigid substrate. However, size limitations, complex processes, and high costs are still barriers that need to be overcome.…”

Section: Introductionmentioning

confidence: 99%

Flexible Mica-Based PZT Sensor for Real-Time Monitoring of the Airflow

Miao

Zhai

et al. 2023

Crystals

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Pipeline leakage causes enormous safety and economic concerns; therefore, sensors which are high-performance and durable are in high demand for improving monitoring accuracy and for avoiding economic loss. In this work, mica-based flexible PZT sensors showed high sensitivity, with 140 mV N−1 and 467 mV N−1 for the output voltage, with regard to the tapping and bending modes, respectively. They can monitor airflow in normal conditions with high sensitivity and a linearity of 424 mV MPa−1 and 0.99, respectively. In the event of a pipeline leak, the mica-based sensors exhibited a rapid response time as short as 0.578 s. Furthermore, they generated distinct voltage levels at different distances from the leakage point, thus providing valuable information for accurately locating the source of the leakage.

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Autonomous Microcapillary Drug Delivery System Self‐Powered by a Flexible Energy Harvester

Cited by 11 publications

References 45 publications

iP & OEIP – Cytokinin Micro Application Modulates Root Development with High Spatial Resolution

iP & OEIP – Cytokinin Micro Application Modulates Root Development with High Spatial Resolution

Recent advancements in piezoelectric energy harvesting for implantable medical devices

Flexible Mica-Based PZT Sensor for Real-Time Monitoring of the Airflow

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