Autonomous production of 1,4-butanediol via a de novo biosynthesis pathway in engineered Escherichia coli

Liu, Huaiwei; Lu, Ting

doi:10.1016/j.ymben.2015.03.009

Cited by 109 publications

(58 citation statements)

References 49 publications

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“…In addition to this commonly used pathway, alternative potential routes via α-ketoglutarate, glutamate or acetyl-CoA were described (Yim et al, 2011). Conversion of xylose to 1,4-butanediol has also been described (Liu and Lu, 2015).…”

Section: Introductionmentioning

confidence: 99%

Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440

Narancic

Kenny

et al. 2020

Front. Microbiol.

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Section: Introductionmentioning

confidence: 99%

Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440

Narancic

Kenny

et al. 2020

Front. Microbiol.

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“…127 The quorum sensing system has been successfully incorporated into 1,4butanediol (BD) biosynthesis pathway in E. coli and achieved autonomous BD production. 128 Genetic switches are like on-off switches that redistribute carbon flux among vari ous pathways via inducermediated control of the key enzymes of the metabolic network. 129 A simple example is a tetR/lacI-based genetic switch of citrate synthase (gltA) designed for isopropanol production.…”

Section: Strategies In Metabolic Engineering Of Glycolysismentioning

confidence: 99%

Glycolysis and Its Metabolic Engineering Applications

Wang¹,

Yan²

2017

Engineering Microbial Metabolism for Chemical Synthesis

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IntroductionMicroorganisms play a pivotal role in the degradation of complex carbon sources in nature and could survive in different conditions due to the genetically coined cellular metabolism. Cellular metabolism of microorg anisms is defined as the sum of biochemical processes that involves the conversion of environmental nutrients into simple biosynthetic building blocks and energy in the cells. Within these metabolic processes, catabo lism is responsible for breakdown of complex molecules into simple molecules, producing energy, reducing power, and precursor intermedi ates for other metabolic processes like anabolism. The central catabolic pathways include Embden-Meyerhof-Parnas (EMP) pathway, pentose phosphate (PP) pathway, Entner-Doudoroff (ED) pathway, and the tricar boxylic acid (TCA) cycle. The EMP pathway, also known as glycolysis

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“…IPA is a bio-based building block, obtainable by the cycloaddition of bio-acrylic acid and bio-isoprene units, or directly via the fermentation of biomasses [2,3]. Solvent free polycondensation with a bio-based glycol, such as 1,4-butanediol [4][5][6], can lead to a completely bio-based homopolymer, poly(butylene isophthalate) (PBI).…”

Section: Introductionmentioning

confidence: 99%

Enthalpy Relaxation, Crystal Nucleation and Crystal Growth of Biobased Poly(butylene Isophthalate)

et al. 2020

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The crystallization behavior of fully biobased poly(butylene isophthalate) (PBI) has been investigated using calorimetric and microscopic techniques. PBI is an extremely slow crystallizing polymer that leads, after melt-crystallization, to the formation of lamellar crystals and rather large spherulites, due to the low nuclei density. Based upon quantitative analysis of the crystal-nucleation behavior at low temperatures near the glass transition, using Tammann’s two-stage nuclei development method, a nucleation pathway for an acceleration of the crystallization process and for tailoring the semicrystalline morphology is provided. Low-temperature annealing close to the glass transition temperature (Tg) leads to the formation of crystal nuclei, which grow to crystals at higher temperatures, and yield a much finer spherulitic superstructure, as obtained after direct melt-crystallization. Similarly to other slowly crystallizing polymers like poly(ethylene terephthalate) or poly(l-lactic acid), low-temperature crystal-nuclei formation at a timescale of hours/days is still too slow to allow non-spherulitic crystallization. The interplay between glass relaxation and crystal nucleation at temperatures slightly below Tg is discussed.

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Autonomous production of 1,4-butanediol via a de novo biosynthesis pathway in engineered Escherichia coli

Cited by 109 publications

References 49 publications

Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440

Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440

Glycolysis and Its Metabolic Engineering Applications

Enthalpy Relaxation, Crystal Nucleation and Crystal Growth of Biobased Poly(butylene Isophthalate)

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