Autophagy Activation and Antiviral Activity by a Licorice Triterpene

Laconi, Sergio; Madeddu, Maria Antonietta; Pompei, Raffaello

doi:10.1002/ptr.5189

Cited by 35 publications

(24 citation statements)

References 9 publications

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“…After 24 h of treatment, Beclin 1 production induced by GL was more than two fold higher than that was induced by rapamycin, the reference compound. GL was a strong inducer of Beclin 1, which inhibited the replication of herpes simplex virus type 1 (HSV1) 26 . Therefore, GL possessed its anti-HSV1 activity by establishing a resistant state to HSV1 replication.…”

Section: The Antiviral Active Components and Their Possible Mechanismmentioning

confidence: 99%

The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb

Wang

Yang

Yuan

et al. 2015

Acta Pharmaceutica Sinica B

459

293

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Licorice is a common herb which has been used in traditional Chinese medicine for centuries. More than 20 triterpenoids and nearly 300 flavonoids have been isolated from licorice. Recent studies have shown that these metabolites possess many pharmacological activities, such as antiviral, antimicrobial, anti-inflammatory, antitumor and other activities. This paper provides a summary of the antiviral and antimicrobial activities of licorice. The active components and the possible mechanisms for these activities are summarized in detail. This review will be helpful for the further studies of licorice for its potential therapeutic effects as an antiviral or an antimicrobial agent.

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Section: The Antiviral Active Components and Their Possible Mechanismmentioning

confidence: 99%

The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb

Wang

Yang

Yuan

et al. 2015

Acta Pharmaceutica Sinica B

459

293

View full text Add to dashboard Cite

show abstract

“…In one study, Laconi et al reported that glycyrrhizin, an active component of licorice, increased the production of Beclin 1 twofold more than rapamycin, a reference compound 26. Beclin 1 is an autophagy activator that was shown to inhibit the replication of HSV-1 27.…”

Section: Discussionmentioning

confidence: 99%

Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir

Polansky

Javaherian

Itzkovitz

2016

DDDT

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BackgroundThis paper reports the results of a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on the number of genital herpes outbreaks. The results in this study were compared to those published in clinical studies of acyclovir, valacyclovir, and famciclovir.MethodsThe framework was a retrospective chart review. The population included 139 participants. The treatment was one to four capsules of Gene-Eden-VIR/Novirin per day. The duration of treatment was 2–48 months. The study included three controls recommended by the US Food and Drug Administration (FDA): baseline, no treatment, and dose response.ResultsThe treatment decreased the number of outbreaks per year in 90.8% of the participants. The treatment also decreased the mean number of outbreaks per year from 7.27 and 5.5 in the control groups to 2.39 (P<0.0001 and P<0.001, respectively). The treated participants reported no adverse experiences. Out of the 15 tests that compared Gene-Eden-VIR/Novirin to the three drugs, Gene-Eden-VIR/Novirin had superior efficacy in eight tests, inferior efficacy in three tests, and comparable efficacy in four tests. Gene-Eden-VIR/Novirin also had superior safety.ConclusionThe clinical study showed that the natural Gene-Eden-VIR/Novirin decreases the number of genital herpes outbreaks without any side effects. The study also showed that the clinical effects reported in this study are mostly better than those reported in the reviewed studies of acyclovir, valacyclovir, and famciclovir.

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“… Prunella vulgaris Fam: Lamiaceae Self heal Betulinic acid Hyperoside Delphinidin Lupeol HIV-1 and Ebola virus [ 68 ] Herpes simplex virus-1 & 2 [ 68 ] 6. Glycyrrhiza glabra Family: Fabaceae Licorice Glycyrrhizin Glycyrrhetic acid Liquiritin Isoliquiritin HCV [ 69 , 70 ] Influenza virus [ 71 ] HSV1 [ 72 ] 7. Caesalpinia pulcherrima Family:Leguminosae Peacock flower Lupeol β-amyrin, Peltoginoids Homoisoflavonoide Herpes viruses, adenovirus [ 73 ] 8.…”

Section: Potential Of Medicinal Plants Against Covid-19mentioning

confidence: 99%

Combating COVID-19: The role of drug repurposing and medicinal plants

Khan

Al-Balushi

2021

Journal of Infection and Public Health

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Background A novel corona virus-2 disease has spread to 213 countries and territories across the globe. The corona pandemic has claimed more than 548,934 deaths worldwide till the evening of 8 th of July 2020 and the number of confirmed cases is increasing at an alarming rate. Therefore, there is an urgent need to find a treatment or a vaccine for COVID-19 at the earliest. The aim of this mini-review is to give an overview of identified repurposed anti-COVID-19 drugs which are currently under clinical trials. Methods A thorough literature survey was done to retrieve relevant information using various web based search engines such as Google, Google scholar, and various other electronic research databases such as PubMed, Medline, MeSh etc . The findings of the recently published articles, clinical trials, COVID-19 update by World Health Organization etc ., and the opinion of the authors is summarized in this brief review. The antiviral medicinal plants were identified based on their use in Chinese/Indian indigenous systems of medicine, traditional use, published scientific phytochemical studies and/or their effectiveness against upper respiratory infections, severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS). Results The disease is just over six months old and effective prophylactic or therapeutic agents are yet to be developed for COVID-19. Thus, in the absence of an effective therapy, scientific community has rationally considered the drug repurposing approach for the development of anti COVID-19 drugs. Various studies and clinical trials involving antimalarial drugs, anti-HIV drugs, anti-hepatitis drugs, anti-parasitic drug, anti-inflammatory drugs, the combination of antimalarial and macrolide antibiotic and few other molecules identified through drug repurposing are currently underway to combat COVID-19. Due emphasis is also given to develop novel corona vaccines for the prophylaxis and to identify drugs for adjunct/supportive therapy. Several medicinal plants along with their major phytochemicals exhibiting antiviral activity are identified for further exploration. It is anticipated that these natural products might also play an important role in combating COVID-19. Conclusions Use of drug repurposing strategy to develop anti COVID-19 drugs and exploring antiviral medicinal plants as adjunct or supportive therapy appears to be a viable option. Therefore, it is the need of the hour to work in parallel on different strategies such as genetic engineering, in silico approach, herbal remedies and drug repositioning to achieve the common goal of finding a safe and effective treatment for COVID-19 at the earliest.

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Autophagy Activation and Antiviral Activity by a Licorice Triterpene

Cited by 35 publications

References 9 publications

The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb

The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb

Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir

Combating COVID-19: The role of drug repurposing and medicinal plants

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