Autophagy activation induced by let-7 microRNA overexpression counteracts disease phenotype in Machado-Joseph disease mouse models

Duarte, Sónia; Estremores, Beatriz Filipa Varela; Cunha-Santos, Janete; Miranda, Catarina; Barata, João; Spada, Albert La; Almeida, Luís De

doi:10.3389/conf.fncel.2019.01.00026

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Mirnas In Brain1

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2021

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“…Let-7 is considered as one of the key regulators of autophagy with special relevance to polyglutamine disorder. Overexpression of let-7 in this disease activates autophagy and prevents the disease ( Duarte et al., 2020 ). In AD, two sets of let-7 miRNAs, i.e., let-7b and let-7e get overexpressed and a high amount of these two miRNAs is found in the cerebrospinal fluid (CSF) of AD patients ( Derkow et al., 2018 ).…”

Section: Mirnas In Brainmentioning

confidence: 99%

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Section: Mirnas In Brainmentioning

confidence: 99%