Autophagy and Cancer Metastasis: A Trojan Horse

Alizadeh, Javad; Lorzadeh, Shahrokh; Ghavami, Saeid

doi:10.1136/jim-2021-002016

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…LC3β comprised of LC3β-I and LC3β-II with a molecular weight of 16 kDa and 14 kDa, respectively, are detected in Western blot. Furthermore, LC3β-I is a cytosolic protein, and LC3β-II is positioned on the autophagosome membrane, demonstrating the generation or degradation of autophagosomes [ [65] , [66] , [67] ]. The LC3β-II:LC3β-I ratio was applied to determine the LC3 conversion as an autophagosome marker, used to monitor autophagy.…”

Section: Resultsmentioning

confidence: 99%

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Potential role of TGFΒ and autophagy in early cerebellum development

Dalvand¹,

Rosa²,

Ghavami³

et al. 2022

Biochemistry and Biophysics Reports

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Section: Resultsmentioning

confidence: 99%

“…4 A and B). This proposes an increase in autophagosome creation or a decrease in autophagosome degradation [ 67 , 68 ].…”

Section: Resultsmentioning

confidence: 99%

Potential role of TGFΒ and autophagy in early cerebellum development

Dalvand¹,

Rosa²,

Ghavami³

et al. 2022

Biochemistry and Biophysics Reports

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“…Interestingly, β-catenin serves as a co-repressor of p62 when Wnt signaling is active. GSK3β is a critical inhibitory regulator of Wnt signaling and has been demonstrated to promote autophagy through phosphorylation of the tuberous sclerosis complex (TSC) [24,32] (see Figure 2). In epithelial cell-cell adhesion and Wnt signaling, the E-cadherin/β-catenin complex plays a critical role.…”

Section: Emerging Links Between Wnt Signaling and Autophagy In Gliomamentioning

confidence: 99%

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

Behrooz¹,

Talaie²,

Jusheghani

et al. 2022

IJMS

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116

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Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments, including surgery, chemotherapy, and radiation, are palliative at best. The design of effective and targeted chemotherapeutic strategies for the treatment of GBM require a thorough analysis of specific signaling pathways to identify those serving as drivers of GBM progression and invasion. The Wnt/β-catenin and PI3K/Akt/mTOR (PAM) signaling pathways are key regulators of important biological functions that include cell proliferation, epithelial–mesenchymal transition (EMT), metabolism, and angiogenesis. Targeting specific regulatory components of the Wnt/β-catenin and PAM pathways has the potential to disrupt critical brain tumor cell functions to achieve critical advancements in alternative GBM treatment strategies to enhance the survival rate of GBM patients. In this review, we emphasize the importance of the Wnt/β-catenin and PAM pathways for GBM invasion into brain tissue and explore their potential as therapeutic targets.

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“…Autophagy protects cells from stress caused by DNA damage, reactive oxygen species (ROS), adenosine triphosphate (ATP) deficiency, and nutrient deprivation [ 17 , 18 , 19 , 20 , 21 ]. In normal cells, autophagy occurs at a basal level, whereas it significantly increases in cancer cells to support their high metabolic energy demands [ 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Alizadeh

Kavoosi

Singh

et al. 2023

Cancers

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Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.

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Autophagy and Cancer Metastasis: A Trojan Horse

Cited by 17 publications

References 27 publications

Potential role of TGFΒ and autophagy in early cerebellum development

Potential role of TGFΒ and autophagy in early cerebellum development

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

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