Autophagy as a modulator of cell death machinery

Noguchi, Masayuki; Hirata, Noriyuki; Tanaka, Tsutomu; Suizu, Futoshi; Nakajima, Hiroshi; Chiorini, John A.

doi:10.1038/s41419-020-2724-5

Cited by 158 publications

(106 citation statements)

References 147 publications

(311 reference statements)

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“…2 ). At present, relevant literature has reported related factors are involved in regulating the interaction between autophagic and cell apoptosis in other tumors, such as Beclin-1, P62, caspase, Bcl-2 and so on [ 51 , 52 ]. It was also found that these related regulatory factors were involved in the interaction between autophagic and apoptosis in colorectal cancer [ 48 , 53 ] ( Fig.…”

Section: The Main Regulatory Factors Of the Interaction Between Autopmentioning

confidence: 99%

The interaction mechanism between autophagy and apoptosis in colon cancer

Xie

Liu

2020

Translational Oncology

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Autophagy and apoptosis play crucial roles in tumorigenesis. Recent studies have shown that autophagy and apoptosis have a cross-talk relationship in anti-tumor therapy. It is well established that apoptosis is one of the main pathways of tumor cell death. While autophagy can occurs in tumors with opposite function: protective autophagy and lethal autophagy. Protective autophagy can inhibit tumor apoptosis induced by anticancer drugs, while lethal autophagy can induce tumor cell apoptosis in cooperation with anticancer drugs. Hence, autophagy and apoptosis have synergistic and antagonistic effects in tumor. Colorectal cancer is a common malignant tumor with high morbidity and mortality. In recent years, colorectal carcinoma has achieved improved clinical efficacy with drug treatment. Nonetheless, increasing drug-resistance limit the treatment efficacy, highlighting the urgency of exploring the molecular events that drive drug resistance. Researchers have found that autophagy is one of the major factors leading to drug resistance in colon cancer. Therefore, elucidating the interaction between autophagy and apoptosis is helpful to improve the efficacy of anticancer drugs in clinical treatment of colorectal cancer. This review attaches great importance to the relationship between autophagy and apoptosis and related factors in colorectal cancer.

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Section: The Main Regulatory Factors Of the Interaction Between Autopmentioning

confidence: 99%

The interaction mechanism between autophagy and apoptosis in colon cancer

Xie

Liu

2020

Translational Oncology

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“…In general, autophagy is initiated to recover ATP levels and avoid cell death when cellular energy is limited, such as during increased AMP/ATP or amino acid starvation (34). However, cellular ATP levels are also fundamental for autophagy initiation, and are required in several steps during autophagy (35,36).…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial fusion mediated by mitofusin 1 regulates macrophage mycobactericidal activity by enhancing autophagy

Ning

Cai

Dai

et al. 2020

Preprint

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Mitochondria as a highly dynamic organelle continuously changes morphology and position during its life cycle. Mitochondrial dynamics including fission and fusion play a critical role in maintaining functional mitochondria for ATP production, which is directly linked to host defense against Mtb infection. However, how macrophages regulate mitochondrial dynamics during Mycobacterium tuberculosis (Mtb) infection remains elusive. In this study, we found that Mtb infection induced mitochondrial fusion through enhancing the expression of mitofusin 1 (MFN1), which resulted in increased ATP production. Silencing MFN1 inhibited mitochondrial fusion and subsequently reduced ATP production, which, in turn, severely impaired macrophage mycobactericidal activity by inhibiting autophagy. Impairment of mycobactericidal activity and autophagy was replicated using oligomycin, an inhibitor of ATP synthase. In summary, our study revealed MFN1-mediated mitochondrial fusion is essential for macrophage mycobactericidal activity through the regulation of ATP dependent autophagy. MFN1-mediated metabolism pathway might be targets for development of host direct therapy (HDT) strategy against TB.

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“…Autophagy is the dynamic process by which unnecessary or dysfunctional cytosolic proteins and organelles are degraded in order to maintain cell homeostasis. It is activated under extracellular (starvation, hypoxia and infection) and intracellular (accumulation of damaged molecules and high bioenergetics demand) stress conditions (200). Nutrient limitation or starvation is a frequent feature of the cellular microenvironment in the core of solid tumors.…”

Section: Circadian Clock Pancreatic Cancer and Therapymentioning

confidence: 99%

“…Nutrient limitation or starvation is a frequent feature of the cellular microenvironment in the core of solid tumors. The predominant role of autophagy in cancer cells is to confer stress tolerance, which serves to maintain tumor cell survival ( 201 ) by altering metabolic conditions ( 200 ).…”

Section: Circadian Clock Pancreatic Cancer and Therapymentioning

confidence: 99%

Circadian Genes as Therapeutic Targets in Pancreatic Cancer

et al. 2020

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Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.

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Autophagy as a modulator of cell death machinery

Cited by 158 publications

References 147 publications

The interaction mechanism between autophagy and apoptosis in colon cancer

The interaction mechanism between autophagy and apoptosis in colon cancer

Mitochondrial fusion mediated by mitofusin 1 regulates macrophage mycobactericidal activity by enhancing autophagy

Circadian Genes as Therapeutic Targets in Pancreatic Cancer

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