Autophagy protects against high uric acid-induced hepatic insulin resistance

He, Furong; Wang, Mei; Zhao, Hairong; Xie, De; Lv, Jun; Liu, Weidong; Yu, Wei; Wang, Qiang; Chen, Binyang; Xu, Chenxi; Yamamoto, Tetsuya; Koyama, Hidenori

doi:10.1016/j.mce.2022.111599

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…Autophagy is a highly conserved regulatory process and close to metabolism that exists widely in eukaryotic cells, which helps cells recycle damaged organelles, thereby maintaining cellular homeostasis. Meanwhile, studies have shown that autophagy could ameliorate IR . Therefore, we hypothesized that walnut-derived peptides could attenuate mitochondrial function through autophagy, leading to the amelioration of IR.…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, studies have shown that autophagy could ameliorate IR. 37 Therefore, we hypothesized that walnut-derived peptides could attenuate mitochondrial function through autophagy, leading to the amelioration of IR. As shown in Figure 5A−C, compared with the control group, the levels of Beclin-1 and LC3-II/LC3-I in the model group were significantly decreased, and the levels of p62 were significantly increased (P < 0.05).…”

Section: Fraction 3−10 Kda and Lp5 Protect Mitochondrial Function And...mentioning

confidence: 99%

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Walnut-Derived Peptides Promote Autophagy via the Activation of AMPK/mTOR/ULK1 Pathway to Ameliorate Hyperglycemia in Type 2 Diabetic Mice

Hou

Zhao

et al. 2023

J. Agric. Food Chem.

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Autophagy flux plays a significant protective role in type 2 diabetes mellitus (T2DM). However, the mechanisms by which autophagy mediates insulin resistance (IR) to ameliorate T2DM remain unclear. This study explored the hypoglycemic effects and mechanisms of walnut-derived peptides (fraction 3−10 kDa and LP5) in streptozotocin and high-fat-diet-induced T2DM mice. Findings revealed that walnut-derived peptides reduced the levels of blood glucose and FINS and ameliorated IR and dyslipidemia. They also increased SOD and GSH-P X activities and inhibited the secretion of TNF-α, IL-6, and IL-1β. Additionally, they increased the levels of ATP, COX, SDH, and MMP of liver mitochondria. Western blotting indicated that walnut-derived peptides upregulated LC3-II/LC3-I and Beclin-1 expression, while they down-regulated p62 expression, which may be associated with the activation of the AMPK/mTOR/ULK1 pathway. Finally, the AMPK activator (AICAR) and inhibitor (Compound C) were used to verify that LP5 could activate autophagy through the AMPK/mTOR/ULK1 pathway in IR HepG2 cells.

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Section: Resultsmentioning

confidence: 99%

Section: Fraction 3−10 Kda and Lp5 Protect Mitochondrial Function And...mentioning

confidence: 99%