Autopsy findings of patients with urological neoplasms

Abstract

Background.A study was carried out to gain extensive understanding of the disease status in patients who had suffered and died of urological neoplasms. Methods. The subjects were 524 patients who had died at the Department of Urology of Gunma Cancer Center. The autopsy rate for each urological, neoplasm, the extent of the disease, and incidental diseases were analyzed. Results. Autopsies were performed in 27.1% (142/524) of the patients. Frequent metastatic sites were the lymph nodes, bone, and lung in prostate neoplasms; the lymph nodes, liver, and lung in bladder neoplasms; and the lymph nodes, lung, and bone in kidney neoplasms. In the 116 patients with these three major urological neoplasms, the autopsy findings of all patients were compatible with progression of the disease, except for 5 cases (acute myocardial infarction in 2 and liver failure in 3). Multiple primary cancers were seen in 21.6% (25/116), and other cancers that caused death, apart from those at urological sites, were confirmed in 7 patients (pancreas in 2, and esophagus, lung, gallbladder, liver, and uterus in 1 patient each). Conclusion. Autopsies revealed the macroscopic and microscopic extent of the disease and the presence of incidental disease beyond the diagnosis made in the patient's lifetime.

A case report of prostate cancer metastasis to the stomach resembling undifferentiated-type early gastric cancer

“…In prostate cancer, metastases to bones and lymph nodes are common, but metastasis to the stomach is extremely rare [ 3 ]. Prostate cancer can occasionally present as a metastatic carcinoma with unknown primary origin; however, the origin of metastasis in such a setting is easily identified by using immunohistochemistry for prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP).…”

Synchronous Association of Squamous Cell Carcinoma of the Larynx and Clear Cell Renal Cell Carcinoma: A Case Report

“…The association of squamous cell carcinoma of the larynx with that of the UADT has been well documented in the literature; the association with renal cell carcinoma is rare. The analysis of several autopsy series has revealed 21.6% of multiple primary cancers in subjects with urological tumors [6]. These tumors were of pancreatic, esophageal, gastric, hepatic origin or localized in the bile ducts or in the gynecological area, there was no laryngeal localization [6], [7].…”