Autoradiographische Untersuchungen des embryonalen DNS-Stoffwechsels nach einmaliger Röntgenganzbestrahlung der Wistarratte am 11. Graviditätstag mit 150 R

Wegner, G

doi:10.1007/bf02047055

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…A similar effect is also known from in vitro studies (Watanabe and Okada 1966;Waiters and Tobey 1970;K6nig and Baisch 1980) and from in vivo observations of the mouse' and rat's forebrain (Wegner 1965;Wegner and Mecking 1969). This finding demands two alternative explanations: First, DNA replication could be arrested in about 66% of the S-stage cells, while the remaining 33% would then represent a relatively inert fraction.…”

Section: Discussionsupporting

confidence: 60%

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Kinetics of telencephalic neural cell proliferation during the fetal regeneration period following a single X-irradiation at the late organogenesis stage

Schmahl

1982

Radiat Environ Biophys

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Summary.A sequential study of the acute effects of prenatal X-irradiation on telencephalic cell population dynamics was performed by combining a pathological evaluation with autoradiographic methods. This study confirmed that a dose of 0,95 Gy affects nearly all neuroblasts in the GI-, G2-, and M-stage lethally. Within ventricular cells staying in the S-phase at the time of X-irradiation, lethal effects are in the range between 50% and 75%. The surviving remainder of these neuroblasts is responsible for subsequent attempts for regeneration of the telencephalic roof. Two subpopulations of the surviving S-phase cells were observed: The first subpopulation which seems to be restricted to the rudiments of the ventricular zone shows a S/G2-blockade for 8-12 h after X-irradiation. Thereafter these cells start again with mitotic activity. The second subpopulation is morphologically manifested by the formation of heterotopic cell nests, i.e., so-called rosettes. These cells continue with an intense DNA-replication after the 12th h post irradiation and proceed to the mitosis stage only after about another 4 -8 h, i.e., the 16th to 20th hour following X-irradiation. These findings indicate the existence of two different pools of regenerative cells within the telencephalic roof, giving rise to either orthotopic or heterotopic growth processes after irradiation injury.

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Section: Discussionsupporting

confidence: 60%

“…Some other studies (Wegner 1965(Wegner , 1966Wegner and Haas 1967) are focussed to changes in the 3H-thymidine labeling potency of neuronal cells during early brain development. Investigations of Fujita et al (1963Fujita et al ( , 1964 include cytokinesis throughout the generation cycle in combination with the spatial organization.…”

Section: Introductionmentioning

confidence: 98%

Kinetics of telencephalic neural cell proliferation during the fetal regeneration period following a single X-irradiation at the late organogenesis stage

Schmahl

1982

Radiat Environ Biophys

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Different teratogenic efficacy to mouse fetal CNS of 5‐azacytidine in combination with X‐irradiation depends on the sequence of successive application

Schmahl

1979

Teratology

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The single treatment of pregnant mice on day 12 post conception with 5-azacytidine (AzaCr), followed by a single irradiation dose of 200 rad two hours later, is exclusively neurotoxic to the fetus, as shown by a severe hypoplasia of the parieto-occipital regions of the telencephalon. This effect is explicable by the specific function of the mitotic cell population for the integrity of the cortex wall. Combining these two hazards in the reverse manner, i.e., irradiation followed by AzaCr, resulted in no general hypoplastic effect in the forebrain and only caused a depletion of cells in the marginal cortex. This indicates a significantly diminished AzaCr sensitivity of fetal cortical cells subsequent to X-irradiation. In addition, rosette-like cell clustering in the cortex of all X-irradiated animals occurs to a similar degree, irrespective of any additional AzaCr-treatment. The only conformity between these different schedules is that a great portion of the surviving cells is most likely in the DNA synthesizing phase at the time of irradiation. It is therefore concluded that rosette formation starts perferentially from cells injured during the S-phase.

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Strahlenbedingte Entwicklungsstörungen

Fritz-Niggli¹

1972

Handbuch Der Medizinischen Radiologie / Encyclopedia of Medical Radiology

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Autoradiographische Untersuchungen des embryonalen DNS-Stoffwechsels nach einmaliger Röntgenganzbestrahlung der Wistarratte am 11. Graviditätstag mit 150 R

Cited by 5 publications

References 11 publications

Kinetics of telencephalic neural cell proliferation during the fetal regeneration period following a single X-irradiation at the late organogenesis stage

Kinetics of telencephalic neural cell proliferation during the fetal regeneration period following a single X-irradiation at the late organogenesis stage

Different teratogenic efficacy to mouse fetal CNS of 5‐azacytidine in combination with X‐irradiation depends on the sequence of successive application

Strahlenbedingte Entwicklungsstörungen

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