1972
DOI: 10.1007/978-3-642-80710-7_6
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Strahlenbedingte Entwicklungsstörungen

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Cited by 4 publications
(6 citation statements)
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“…Although malformation is seldom induced during these stages, these are the most sensitive stages with respect to embryonic lethality. Damaging effects result after single irradiation doses below 25 R and even as low as 5 R (Fritz-Niggli, 1972). 50% embryonic lethality is obtained after single irradiation doses of 100-150 R (Rugh and Wohlfromm, 1965).…”
Section: Discussionmentioning
confidence: 97%
“…Although malformation is seldom induced during these stages, these are the most sensitive stages with respect to embryonic lethality. Damaging effects result after single irradiation doses below 25 R and even as low as 5 R (Fritz-Niggli, 1972). 50% embryonic lethality is obtained after single irradiation doses of 100-150 R (Rugh and Wohlfromm, 1965).…”
Section: Discussionmentioning
confidence: 97%
“…5-17. Yamada, T., Yukawa, O., Asami, K., et al (1982) 1903-1907(Fritz-Niggli, 1959. Radiation-induced malformations in mammals (rabbits) were first described by v. Hippel and Pagenstecher (1907), and the report of v. Klot (1911) is among the first to document radiogenic termination of pregnancy in man.…”
Section: Referencesmentioning
confidence: 99%
“…In contrast to lethality as a single definite endpoint, further complications arise from both the broad variety of inducible malformations and from the degree of their expression. In the past, numerous experiments with rodents have been performed primarily to determine 'critical periods' for the induction of malformations, mainly based on 'morphological defects visible at birth' or skeletal defects observed in selectively stained fetuses (Russell, 1950(Russell, , 1954(Russell, , 1956Rugh, 1969;Fritz-Niggli, 1972;UNSCEAR, 1977). The phase dependency of malformations can be systematised roughly in so far as systemic defects and more organspecific defects are concerned.…”
Section: Malformations In Uteromentioning
confidence: 99%
“…The extension of damage through several cell generations differs basicly from the redistributive tigroid reactions that follow a "primary irritation" of adult neurons and that have been cited above. The extreme radiosensitivity of the DNA in early neuroblasts (see [16,27]) provides evidence that origin and transfer of tigroid maturation damage is mediated by DNA defects. Biogenesis of ribosomal RNA results from transcription in the nucleolar organizer (chromocenter), where the r-DNA acts as matrix for the ribosomal RNA [31,39].…”
Section: Extended Tigroid Maturation Disturbancesmentioning
confidence: 99%
“…Radiation teratogenesis affects particularly the developing central nervous system with its prolonged and complicated genesis [16,21,[25][26][27]56]. Irradiation during early neurogenesis produces predominantly gross anatomical defects due to disturbances of organ induction and due to loss of blastema, the latter partly compensable by cell substitution and tissue reorganization [18,45,46].…”
Section: Introductionmentioning
confidence: 99%