Autoradiographische Untersuchungen über die Verteilung von125J− in der Tracheaischleimhaut und der Parotis thyreoidektomierter Meerschweinchen

Höbel, M; Lehrnbecher, W.

doi:10.1007/bf02043602

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…Similarly, mucus production increased, an effect that is probably due to the fact that iodide is se creted into the airway lumen against a con centration gradient and the osmotic pressure exerted by the iodide ion may increase mu cus volume. Active transport has been dem onstrated in the rat, guinea pig and pigeon [Eichler et al, 1964;Hobel and Lehrnbecher, 1967].The mucolytic effect of potassium iodide has been demonstrated by Marriott and Richards [1974], and improvement in children with asthma has also been docu mented [Siegel, 1964].…”

Section: Discussionmentioning

confidence: 99%

Tracheobronchial Function in Health and Disease

Melville¹,

Ismail²,

Sealy³

1980

Respiration

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The effect of mucolytic and expectorant substances on ciliary beat frequency, mucus transport velocity and mucus production, was investigated in normal and bronchitic rats. The results showed that: (i) N-acetylcysteine and S-carboxymethylcysteine were midly cilioexcitatory at low and ciliodepressive at higher concentrations in both normal and bronchitic rats. A similar pattern was seen in mucus transport velocity, (ii) Bisolvon® enhanced all aspects of mucoeiliary activity in both groups of animals. Sobrepin was less effective than Bisolvon and more effective than Tachoquilin®. (iii) Geleomyrtol, Ozothin and prostaglandin E₁ were all cilioexcitatory in rats with bronchitis. Mucus transport velocity was similarly stimulated by both Geleomyrtol and Ozothin. (iv) Ammonium chloride and potassium iodide enhanced mucoeiliary activity in normal and bronchitic rats, (v) All substances stimulated mucus production, however, the most potent was prostaglandin E₁. The mechanisms for increased mucoeiliary activity involve inter alia the probable cleaving of disulfide bridges, decreased mucosal swelling, altered rheological characteristics and stimulation of adenylate cyclase.

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Section: Discussionmentioning

confidence: 99%