Autoradiographische Untersuchungen über die Zellkinetik der enchondralen Ossifikation der Maus nach Oestrogen- und Testosteronverabreichung

Age-Linked Modification of the Effect of Estrogen on Joints and Cortical Bone of Female Mice

“…Opposing concepts advocate a stimulation of osteoblastic bone formation by estrogens [12]. The problem has recently been brought closer to a solution by the finding that estrogen stimulated the differentiation of fibroblasts into osteoblasts [15,16], rather than the activity of individu al bone forming cells. In order to promote resorptive processes, a com parable transformation of fibroblasts into osteoblasts may, but need not occur, since fibrous tissue as such is well known for its osteolytic properties.…”