Autosomal dominant polycystic kidney disease and minimal trauma: medical review and case report

Hajjar, Karim; Chebl, Ralphe Bou; Kanso, Mohammad; Dagher, Gilbert Abou

doi:10.1186/s12873-018-0192-3

Cited by 9 publications

(8 citation statements)

References 40 publications

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“…It has also been shown that increased levels of proteinuria and urinary albumin excretion correlated with higher risk of severe renal disease and progression to ADPKD [12]. Hematuria in ADPKD has been linked with hemorrhage in the cysts or cyst rapture into collecting ducts while, proteinuria occurs due to impaired reabsorption of proteins by cyst-lined tubular epithelia which may not occur at the initial stage of the disease [13]. The multiple urinary tract infections (UTIs) observed in this study could result to more rapid decline in renal function.…”

Section: Discussionmentioning

confidence: 99%

Evidence of Risk Factors Associated with Autosomal Dominant Polycystic Kidney Disease in Newly Diagnosed Adult Hypertensive Patients in NAUTH Nnewi, Nigeria

Ukibe

Kalu

Emeje

et al. 2022

JPRI

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Aims & objectives: Due to other chronic diseases that are associated with hypertension and kidney disease, little or no attention has been paid to the existence of polycystic kidney disease in Nigeria. The present study aimed at assessing the prevalence of some risk factors of ADPKD among hypertensive adult patients in NAUTH, Nnewi, Anambra State, Nigeria Study design: A cross-sectional and prospective study Place and Duration of Study: The study was carried out at Medical out-patient, cardiology and nephrology units of NAUTH Nnewi between February and June, 2019. Methodology: A total of 160(80 newly diagnosed hypertensive and 80 normotensive subjects) aged between 25-75 years were randomly selected. Estimation of serum electrolytes, urea, creatinine, total calcium, eGFR and total protein, BMI and waist-hip ratio of the subjects were taken were done using standard laboratory methods. Results: 12.5% of the hypertensive subjects have undergone dialysis, 7.5% had kidney transplant, 13.8% had hematuria, 20% had proteinuria, 27.5% had recurrent kidney infection, 15% had kidney stone, 43.8% experienced abdominal/side pain, 20% have had abdominal hernias and 46.3% had elevated urea/creatinine. Mean values of age, BMI and WHR were significantly higher in hypertensive than control subjects (p =.05). Similarly, serum creatinine, urea, sodium and chloride were significantly higher with lower eGFR in hypertensive when compared with control group (p =.05). eGFR in female was significantly lower compared with male hypertensive (p = .05). The mean SBP and DBP were significantly higher in hypertensive compared with control group (p = .05). Conclusion: 30% of the hypertensive subjects had multiple signs and symptoms of ADPKD, suggesting evidence of high prevalence of ADPKD in the hypertensive patients. Routine screening of family members with hypertension and symptomatic cases of hypertension using ultrasound imaging is strongly recommended for confirmation of presence PKD.

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Section: Discussionmentioning

confidence: 99%

Evidence of Risk Factors Associated with Autosomal Dominant Polycystic Kidney Disease in Newly Diagnosed Adult Hypertensive Patients in NAUTH Nnewi, Nigeria

Ukibe

Kalu

Emeje

et al. 2022

JPRI

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“…As observed in our study (Table 6 ), proteinuria and hematuria are common observations in ADPKD [ 30 ]. Whereas hematuria in ADPKD mostly occurs either due to hemorrhage into cysts or cyst rapture into collecting ducts, proteinuria occurs due to impaired reabsorption of proteins by cyst-lined tubular epithelia [ 31 ] but is not usually observed in the early stages [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Demographic, diagnostic and therapeutic characteristics of autosomal dominant polycystic kidney disease in Ghana

et al. 2021

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Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the commonest of the hereditary kidney diseases and mostly ensues in utero with signs delayed until after several decades. This study assessed the demographic, diagnostic (clinical and biochemical features) and therapeutic patterns among ADPKD patients who attended the nephrology unit of Komfo Anokye Teaching Hospital (KATH) from 2007 to 2018. Methods This cross-sectional retrospective analysis of ADPKD patient records was conducted at the nephrology unit of KATH in October 2020. The records of 82 ADPKD was used for this study. Demographic, clinical, biochemical, ultrasonographic and therapeutic data was obtained, organized and analyzed with Statistical Package for the Social Sciences (SPSS). Results ADPKD was most prevalent in people within the ages of 31–40 years (25.6 %), with a male (52.4 %) preponderance. The most common clinical features presented were flank pain (30.5 %) and bipedal swelling (18.3 %). Hypertension (42.7 %), urinary tract infections (UTIs) (19.5 %), and anemia (13.4 %) were the most common complications reported. Average level of HDL-c was higher in females (1.7) than in males (1.2) (p = 0.001). Hematuria (34 %) and proteinuria (66 %) were among the biochemical derangements presented. About 81.7 % had CKD at diagnosis with the majority in stages 1 (27.0 %), 3(23.2 %) and 5 (20.3 %). Poor corticomedullary differentiation was observed in 90.2 % of participants and increased echogenicity was observed in 89.0 % of the participants. Estimated GFR (eGFR) correlated positively with echotexture (r = 0.320, p = 0.005) and negatively with CMD (r= -0.303, p = 0.008). About 95.1 % of patients were on conservative therapy including: 73.2 %, 52.4 %, 22.0 %, 13.4 %, 8.5 % on Irebesartan/Lisinopril, Nifecard XL, Hydralazine, Methyldopa and Bisoprolol respectively for hypertension; 26.8 and 3.7 % on Gliclazide and Metformin respectively for Type 2 diabetes mellitus; 25.6 %, 24.4 and 18.3 % on CaCO3, fersolate and folic acid respectively as nutrient supplements with 4.9 % of participants on renal replacement therapy (RRT). Conclusions ADPKD occurs in people aged ≥ 31 years with a higher male preponderance. Clinical features include flank and abdominal pain, bipedal swelling, headache, amongst others. Uremia, hematuria, proteinuria, decreased eGFR, were the common biochemical derangements reported with higher severity detected in men. The therapeutic interventions mostly involved conservative therapy to manage symptoms and other comorbid conditions and rarely renal replacement therapy (RRT).

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“…A case series of adult patients with ADPKD described several cases of serious bleeding resulting from relatively low-impact events including shock wave lithotripsy, a massage chair, and a fall from standing height. 5 Additionally, hemorrhagic cystic rupture in adult patients has been associated with retroperitoneal hematomas and the development of hypovolemic shock.…”

Section: Discussionmentioning

confidence: 99%

A 13-Year-Old Male With Hematuria and Abdominal Pain Following Low-Impact Trauma

Lalich

Streck

Kane

2020

Clin Pediatr (Phila)

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Autosomal dominant polycystic kidney disease and minimal trauma: medical review and case report

Cited by 9 publications

References 40 publications

Evidence of Risk Factors Associated with Autosomal Dominant Polycystic Kidney Disease in Newly Diagnosed Adult Hypertensive Patients in NAUTH Nnewi, Nigeria

Evidence of Risk Factors Associated with Autosomal Dominant Polycystic Kidney Disease in Newly Diagnosed Adult Hypertensive Patients in NAUTH Nnewi, Nigeria

Demographic, diagnostic and therapeutic characteristics of autosomal dominant polycystic kidney disease in Ghana

A 13-Year-Old Male With Hematuria and Abdominal Pain Following Low-Impact Trauma

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