Autosomal recessive inherited bleeding disorders in Pakistan: a cross-sectional study from selected regions

Naz, Arshi; Jamal, Muhammad Younus; Amanat, Samina; Ujjan, Ikram Din; Najmuddin, Akber; Patel, Humayun; Raziq, Fazle; Ahmed, Nisar; Imran, Ayisha; Shamsi, Tahir

doi:10.1186/s13023-017-0620-6

Cited by 12 publications

(4 citation statements)

References 34 publications

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“… 1 , 3 Pakistan is one of the countries having high rate of consanguineous marriages, so it is expected that RBDs would be more prevalent here as compared to worldwide data, but they largely remain undiagnosed in the region due to lack of specialized diagnostic facilities, lack of public awareness and low clinical suspicion in many cases. 3 , 4 Due to these limitations, there is not much local data regarding frequency and clinical spectrum of these disorders.…”

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confidence: 99%

ChatGPT - Reshaping medical education and clinical management

Jawaid²,

et al. 2023

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Artificial Intelligence is no more the talk of the fiction read in novels or seen in movies. It has been making inroads slowly and gradually in medical education and clinical management of patients apart from all other walks of life. Recently, chatbots particularly ChatGPT, were developed and trained, using a huge amount of textual data from the internet. This has made a significant impact on our approach in medical science. Though there are benefits of this new technology, a lot of caution is required for its use. doi: https://doi.org/10.12669/pjms.39.2.7653 How to cite this: Khan RA, Jawaid M, Khan AR, Sajjad M. ChatGPT - Reshaping medical education and clinical management. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.7653 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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confidence: 99%

ChatGPT - Reshaping medical education and clinical management

Jawaid²,

et al. 2023

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“…A prior study found that factor XI, BSS, and GT deficiencies are all characterized by easy bruising. [20] In our study, seventeen (15.04%) cases had family history of rare bleeding. Frequency of consanguinity was found in 88 (77.9%) cases.…”

Section: Discussionmentioning

confidence: 52%

Frequency of Rare Bleeding Disorders

Khan¹,

Kashif²,

Shah³

et al. 2023

PJMHS

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Objective: The incidence and range of rare hereditary bleeding diseases, as well as the severity of the deficiency and its many clinical presentations, were the subjects of our study. Study Design: Cross-sectional study Place and Duration: Department of Pathology, Northwest School of Medicine Peshawar in the duration from July, 2022 to December, 2022. Methods: Total 850 cases of coagulation disorders were presented in this study. A thorough demographic analysis of the recruited cases was done after receiving informed written consent. After taking note of the symptoms and indicators, a coagulation profile was used to diagnose the patients. With the use of factor tests, the illness severity was evaluated. All of the data was examined using SPSS 23.0. Results: Among 850 cases, 113 (13.3%) patients were had rare bleeding disorders. In 113 cases of rare bleeding disorders, there were majority 70 (61.9%) males and 43 (38.1%) patients were females. Mean age of the cases was 10.5±13.69 years. 47 (41.6%) cases were from urban areas and 66 (58.4%) cases had rural residency. Most common deficiency was factor VII found in 33 (29.2%) cases followed by fibrinogen in 22 (19.5%) cases. 17 (15.04%) cases had family history of rare bleeding. Frequency of consanguinity was found in 88 (77.9%) cases. Most common clinical symptom was bruising, gum bleeding, epistaxis and menorrhagia. Conclusion: We concluded higher frequency of rare bleeding disorders in 13.3% cases. Factor VII deficiency is the most typical uncommon bleeding condition in our community. Due to the high rate of consanguineous marriages in our society, these bleeding diseases are very common. Keywords: Factor deficiency, Rare bleeding disorders, Factor assay, Consanguinity

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“…4 Our region is considered to have a high burden of patients with increased transfusion needs like those born with diseases like hemophilia, thalassemia, platelet function defects and others. [11][12][13] Nevertheless, we have a population consisting of a high number of young adults who can be potential blood donors but the barriers like lack of knowledge, myths and misconceptions, and fears about blood donation process are still a blockage towards achieving 100% voluntary blood donation goal. Our study focused to find out these fears among the blood donors coming to a tertiary care facility and we have tried to determine their association with donors' characteristics.…”

Section: Discussionmentioning

confidence: 99%

Association of blood donation related fears with donors’ characteristics and their impact on future donation

Saqlain,

Irfan,

Riaz

et al. 2023

Int J Res Med Sci

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Background: To find the association of blood donation related fears with the donors’ characteristics like age, education level and previous donation history and to find their impact on future donation. Methods: It was a cross-sectional study carried out at a tertiary care hospital in Lahore, Pakistan, from June to December 2022. A self-designed questionnaire addressing five types of fears was filled from 700 blood donors through interview after taking informed consent. Data was analyzed by using IBM-SPSS V23. Results: Among 700 participants, 91.1% were male with mean age ±SD of 28.9±7.1years and 8.9% were female with mean age of 24.5±3.7years. For previous donation experience, the cohort was divided into five subgroups in which 19.7% had never donated blood and 11.3% had six or more donations. Fears were significantly reduced among donors with frequent donations compared to those with reduced donations. However, 4-5% had some retained fears. Reduced fears were observed in donors with higher education except for the fear of needle. Fears of having blood drawn/seeing blood and fear of fainting were more in younger donors. Out of 5.71% donors who were not willing for voluntary blood donation in future, 95% had fears. Conclusions: Frequent blood donations, higher education level and age more than 30 years were associated with reduced blood donation associated fears among blood donors. The presence of fears has negative relation with willingness for future blood donations.

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Autosomal recessive inherited bleeding disorders in Pakistan: a cross-sectional study from selected regions

Cited by 12 publications

References 34 publications

ChatGPT - Reshaping medical education and clinical management

ChatGPT - Reshaping medical education and clinical management

Frequency of Rare Bleeding Disorders

Association of blood donation related fears with donors’ characteristics and their impact on future donation

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