Availability of Fibrinogen/Albumin ratio in MS attack

Çiçekli, Esen; Sayan, Saadet; Kotan, Dilcan

doi:10.1016/j.msard.2022.103674

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…Prior epidemiological investigations have presented evidence pointing to a potential link between albumin level and risk of MS, though the findings have displayed inconsistencies ( 7 , 10 , 15 ). In the current study, we examined the association between baseline albumin levels in serum and urine and the risk of MS. Our results demonstrated that higher serum albumin level was associated with a decreased risk of MS.…”

Section: Discussionmentioning

confidence: 99%

Albumin and multiple sclerosis: a prospective study from UK Biobank

Chen,

Li,

Zhao

et al. 2024

Front. Immunol.

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BackgroundMultiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system. While previous studies have indicated that albumin, the primary protein in human plasma, may exert influence on the inflammatory process and confer beneficial effects in neurodegenerative disorders, its role in the context of MS has been underexplored. Here, we aimed to explore the link between albumin and the risk of MS.MethodsEmploying data from the UK Biobank, we investigated the association between baseline levels of serum and urine albumin and the risk of MS using Cox proportional hazards regression analysis.ResultsA higher baseline level of serum albumin was associated with a lower risk of incident MS (HR=0.94, 95% CI: 0.91–0.98, P=7.66E-04). Subgroup analysis revealed a more pronounced effect in females, as well as participants with younger ages, less smoking and deficient levels of vitamin D. Conversely, no association was identified between baseline microalbuminuria level and risk of incident MS.ConclusionHigher serum albumin level at baseline is linked to a reduced risk of MS. These results contribute to an enhanced understanding of albumin’s role in MS, propose the potential use of albumin as a biomarker for MS, and have implications for the design of therapeutic interventions targeting albumin in clinical trials.

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Section: Discussionmentioning

confidence: 99%

Albumin and multiple sclerosis: a prospective study from UK Biobank

Chen,

Li,

Zhao

et al. 2024

Front. Immunol.

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“…As a novel inflammatory serological marker, FAR has promising predictive ability in a variety of diseases, such as various tumors (pancreatic, esophageal, and liver cancers) ( 39 – 41 ), cardiovascular diseases ( 30 , 42 ), and in estimating the risk of hemorrhagic transformation in patients with acute ischemic stroke ( 43 ). However, a study including 40 patients with MS found no statistically significant correlation between the mean EDSS score and peripheral blood FAR ( P > 0.05) ( 44 ). The relationship between peripheral blood FAR and inflammatory demyelinating diseases of the CNS requires further exploration.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of patients with MOG-IgG associated disorders and analysis of the relationship between fibrinogen-to-albumin ratio and the severity at disease onset

Wang

et al. 2023

Front. Neurol.

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ObjectiveThe study aimed to investigate the differences in clinical features between pediatric and adult patients with first-episode MOG-IgG associated disorders (MOGAD) and evaluate the relationship between the fibrinogen-to-albumin ratio (FAR) and the severity of neurological deficits at disease onset.MethodsWe retrospectively collected and analyzed biochemical test results, imaging characteristics, clinical manifestations, expanded disability status scale (EDSS) score, and FAR. The Spearman correlation analysis and logistic regression models were used to examine the association between FAR and severity. Receiver operating characteristic (ROC) curve analysis was to analyze the predictive ability of FAR for the severity of neurological deficits.ResultsFever (50.0%), headache (36.1%), and blurred vision (27.8%) were the most common clinical manifestations in the pediatric group (<18 years old). However, in the adult group (≥18 years old), the most common symptoms were blurred vision (45.7%), paralysis (37.0%), and paresthesia (32.6%). Fever was more common in the pediatric group, while paresthesia was more common in the adult patients, with all differences statistically significant (P < 0.05). The most frequent clinical phenotype in the pediatric group was acute disseminated encephalomyelitis (ADEM; 41.7%), whereas optic neuritis (ON; 32.6%) and transverse myelitis (TM; 26.1%) were more common in the adult group. The differences in clinical phenotype between the two groups were statistically significant (P < 0.05). In both pediatric and adult patients, cortical/subcortical and brainstem lesions were the most common lesions on cranial magnetic resonance imaging (MRI), whereas, for spinal MRI, cervical and thoracic spinal cord lesions were the most commonly observed. According to binary logistic regression analysis, FAR was an independent risk factor for the severity of neurological deficits (odds ratio = 1.717; 95% confidence interval = 1.191–2.477; P = 0.004). FAR (r = 0.359, P = 0.001) was positively correlated with the initial EDSS score. The area under the ROC curve was 0.749.ConclusionThe current study found age-dependent phenotypes in MOGAD patients as ADEM was more commonly observed in patients < 18 years old, while ON and TM were more frequently found in patients ≥18 years old. A high FAR level was an independent indicator for more severe neurological deficits at disease onset in patients with a first episode of MOGAD.

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“…After brain trauma, it was found that compared with serum, IL-6 in cerebrospinal fluid increased 40-100 times, and the levels of some acute-phase proteins, including Fib, increased accordingly, triggering a positive feedback loop, which exacerbated the inflammatory reaction by increasing IL-6 levels (25). High Fib levels aggravate inflammatory, autoimmune, and neoplastic diseases (31)(32)(33). Zhang et al reported that patients with anti-NMDAR encephalitis and high Fib levels obtained poor effects after first-line treatment (14).…”

Section: Figurementioning

confidence: 99%

“…In addition, other researchers have indicated that a high FARP level is independently associated with the risk of hemorrhagic transformation after acute cerebral ischemia (41). In patients with MS relapses, FARP levels were significantly higher, which could place this factor as a useful indicator of relapses (32). However, few studies have assessed the role of FARP in autoimmune diseases of the CNS.…”

Section: Figurementioning

confidence: 99%

Fibrinogen-to-albumin ratio percentage: An independent predictor of disease severity and prognosis in anti-N-methyl-D-aspartate receptor encephalitis

Shao²,

Song³

et al. 2023

Front. Neurol.

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PurposeThis retrospective study aimed to investigate the relationship between fibrinogen-to-albumin ratio percentage (FARP) and disease severity and prognosis in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis.MethodsMedical records and clinical characteristics from 181 patients with anti-NMDAR encephalitis were included. The modified Rankin Scale (mRS) was used to analyze disease severity and prognosis at admission and discharge, and correlations between FARP, disease severity, and prognosis were analyzed. Receiver operating characteristic (ROC) curves were used to evaluate the efficiency of FARP in assessing disease severity and prognosis.ResultsCompared to the control group, patients with anti-NMDAR encephalitis had higher fibrinogen (Fib) levels (P < 0.001), neutrophil counts (P < 0.001), and FARP levels (P < 0.001) but had lower albumin levels (P = 0.003). The enrolled patients were divided into mild-to-moderate and severe groups according to their mRS scores both at admission and discharge. FARP levels were significantly elevated in the severe group compared to the mild-to-moderate group among patients with anti-NMDAR encephalitis both at admission and discharge (admission 6.0 vs. 7.40, P < 0.001; discharge 6.43 vs. 8.18, P<0.001). Indeed, the mRS scores at admission (56 vs. 26%, P < 0.001) and discharge (26 vs. 11%, P = 0.006) in the high FARP group were significantly higher than those in the low FARP group. Furthermore, FARP was positively correlated with the mRS scores at admission (r = 0.383, P < 0.001) and discharge (r =0.312, P < 0.001). In the multivariate analysis, FARP was significantly associated with disease severity (odds ratio [OR] = 1.416, 95% confidence interval [CI] = 1.117-1.795, P = 0.004) and prognosis (OR = 1.252, 95% CI = 1.010-1.552, P = 0.040). FARP-based ROC curves predicted disease severity, with a sensitivity of 0.756, a specificity of 0.626, and an area under the ROC curve of 0.722 (95% CI = 0.648–0.796, P < 0.001*). The ROC curve predicted the disease prognosis with a sensitivity of 0.703, a specificity of 0.667, and an area under the ROC curve of 0.723 (95% CI = 0.629–0.817, P < 0.001*).ConclusionOur results indicate that FARP is a novel predictive marker for disease severity and prognosis of anti-NMDAR encephalitis.

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Availability of Fibrinogen/Albumin ratio in MS attack

Cited by 8 publications

References 25 publications

Albumin and multiple sclerosis: a prospective study from UK Biobank

Albumin and multiple sclerosis: a prospective study from UK Biobank

Clinical features of patients with MOG-IgG associated disorders and analysis of the relationship between fibrinogen-to-albumin ratio and the severity at disease onset

Fibrinogen-to-albumin ratio percentage: An independent predictor of disease severity and prognosis in anti-N-methyl-D-aspartate receptor encephalitis

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