Masonry wall is a key construction subsystem, but it embodies significant environmental and energy burdens within the life cycle of buildings. Soil-cement bricks and blocks stand as an alternative low-cost masonry material, but despite the widespread claim to be environmentally friendly, more systematic investigation is lacking. This study aimed to assess the life cycle environmental and energy performance of 1.0 m2 of a soil-cement brick masonry wall from cradle-to-construction in terms of carbon, energy, and water footprints, and fossil and mineral resource use, as well as compare it with conventional technologies such as ceramic and concrete block masonries in Brazil. Results showed that raw materials are a major contribution to soil cement masonry walls, followed by the joints and links with columns, in which cement stands out among other inputs. Hydraulic pressing in brick production had a negligible burden increase compared with manual pressing. The PVA mortar joint outperformed the PVA glue one, whereas resin coating performed better than cement mortar. In comparison with ceramic and concrete masonry walls, the soil cement masonry presented overall better environmental and energy performance and was the least affected by the inclusion of finishing coating layers and transport of materials in the sensitivity analysis scenarios, although improved scenarios of conventional options could be competitive, e.g., ceramic masonry with blocks produced by firing reforested wood for the carbon footprint. Scale-up analysis revealed that widespread deployment of soil cement masonry in the built environment would substantially avoid environmental and energy burdens compared with conventional technologies.