Avaliação da analgesia pós-operatória da metadona, da cetamina ou da sua associação em gatas submetidas a ovariossalpingo-histerectomia

Padilha, Vanessa Sasso; Tocheto, Ronise; Beier, Suzane Lílian; Volpato, Julieta; Oleskovicz, Nilson

doi:10.1590/1678-6930

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…A correlação entre as escalas nesse momento foi fraca (r = 0,18). A dificuldade na avaliação da dor na primeira hora pós-cirúrgica foi relatada por Padilha et al (2015), em que 54,1% das gatas avaliadas apresentaram excitação neste momento. Duas horas após a cirurgia (M2) no somatório de pontos pela EDM Unesp-Botucatu o MPOS apresentou valores maiores que M0, e MPRE apresentou valores menores que o MPOS.…”

Section: Resultsunclassified

Effects of meloxicam and ketorolac in cats undergoing elective ovariohysterectomy

Padilha¹,

Tocheto²,

Volpato³

et al. 2022

Pubvet

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Nosso objetivo foi avaliar a analgesia preemptiva do meloxicam e cetorolaco, e seus efeitos sobre as enzimas renais, hepáticas e segurança clínica digestiva em gatas submetidas à ovariohisterectomia. Vinte e quatro gatos, os quais foram alocados em quatro grupos (n = 6), foram utilizados. Os animais receberam meloxicam (MPRE) ou cetorolaco (CPRE) antes da indução anestésica e solução salina após o procedimento cirúrgico. Inversamente, receberam solução salina antes da indução anestésica e meloxicam (MPOS) ou cetorolaco (CPOS) após o procedimento cirúrgico. Os tempos (T0-T6) avaliados no período cirúrgico estão de acordo com o procedimento cirúrgico. Em T0, T2 e T6, amostras de sangue foram coletadas para dosagem de cortisol. No pós-operatório, os animais foram avaliados nas escalas visual analógica (EVA) e de dor multidimensional em felinos (EDM Unesp-Botucatu), seus perfis renal e hepático e presença de vômito e diarreia por 3 dias. Para frequência cardíaca (FC), os valores em MPOS foram maiores que em MPRE (T1, T2 e T5) e em CPOS foram maiores que em CPRE (T1, T2 e T6). Para a concentração de cortisol, os valores no CPOS foram maiores do que no CPRE, MPRE e MPOS (T0 e T6), e no CPOS foram maiores do que no CPRE e MPRE (T2). Para o escore de dor UNESP-Botucatu MPS, os valores do MPRE foram maiores que do MPOS (apenas no M2). Concluímos que não houve analgesia preemptiva para meloxicam e cetorolaco. Ambas as drogas mostraram-se seguras nas avaliações renal e hepática. No sistema digestivo, foi observada uma incidência reduzida de distúrbios gastrointestinais.

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Section: Resultsunclassified

Effects of meloxicam and ketorolac in cats undergoing elective ovariohysterectomy

Padilha¹,

Tocheto²,

Volpato³

et al. 2022

Pubvet

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“…Our study shows that ketamine produced an isolated antinociceptive effect, probably because the IV bolus administration, followed by continuous IV infusion throughout the surgical procedure, maintained adequate plasma concentrations for sustained analgesia. A study of ketamine (0.5 mg/kg) as the pre-anesthetic medication in cats showed that ketamine alone does not produce satisfactory analgesia postoperatively [ 40 ]. We believe that the use of a single bolus dose may be insufficient to maintain adequate plasma concentration for sustained analgesia; thus, continuous IV infusion can resolve this issue.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and analgesic effect of continuous intravenous infusion of maropitant, lidocaine and ketamine alone or in combination in cats undergoing ovariohysterectomy

et al. 2021

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Background Multimodal analgesia consists of the combination of analgesic drugs at low doses to act in different places along the path of pain. Studies with continuous infusion of analgesic drugs in cats are not common. This study aimed to evaluate the analgesic effect of maropitant, lidocaine and ketamine alone or in combination (intravenous bolus + subsequent continuous intravenous infusion) in the management of acute postoperative pain in cats undergoing ovariohysterectomy. Seventy healthy cats undergoing an ovariohysterectomy received a standard anesthetic protocol consisting of acepromazine and morphine, propofol (anesthesia induction), and isoflurane (anesthesia maintenance). The animals were stratified into seven groups (n = 10 in each group): control (CG), maropitant (MG), lidocaine (LG), ketamine (KG), maropitant + lidocaine (LMG), maropitant + ketamine (KMG), and maropitant + lidocaine + ketamine (LKMG). All drugs were injected first as an intravenous bolus and then by continuous intravenous infusion. During surgery, esophageal temperature, respiratory rate, heart rate, oxygen saturation, expired isoflurane concentration, and partial pressure of carbon dioxide at the end of expiration were evaluated at 7 time points. Postoperative pain was evaluated for 6 h after extubation using the visual analogue scale and the UNESP-Botucatu multidimensional composite pain scale for assessing postoperative pain in cats. Results Adverse effects related to maropitant, lidocaine and ketamine infusion were not observed. Pain scores were lower in the MG, KG and LG groups when compared to the CG group using both scales. Although pain scores were also lower in all combination groups than CG, more animals in these groups required rescue analgesia compared to MG. This indicates that the postoperative analgesic effect of all drugs, either alone or in combination, confers analgesia, although the combinations did not promote greater analgesia. Conclusions Continuous intravenous infusion of maropitant, lidocaine, and ketamine alone induces postoperative analgesic effect in cats undergoing ovariohysterectomy, but combinations of these drugs did not increase the analgesic effect. No adverse effect was observed with any drug or their combination.

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“…O estresse foi citado como uma causa natural da diminuição de linfócitos, e diminuições do número de outras células do sistema leucocitário, pois os estímulos estressores eleva o cortisol (Rhodes 2005;Campos et al, 2008;Padilha et al, 2015;. Semelhante aos observados nos animais dos grupos GR3, GR4 e GR5 no momento M0.…”

Section: Resultsunclassified

Influência de cinco protocolos anestésicos sobre o hemograma de coelhos (Oryctolagus cuniculus familiaris)

Felipe¹

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The anesthetic techniques have been evolving significantly providing comfort, humanity and analgesia to the animals in surgical and outpatient procedures. Local action bupivacaine hydrochloride is often used for rapid procedures involving small areas, and ketamine hydrochloride, which in addition to cause sedation in the animal, also has the utility for chemical containment. They have the ability and property to be associated during a procedure to get a sum of their action or to decrease unnecessary doses. Thirty adult rabbits were divided into five groups (GR) of equal numbers (n = 6), to analyze the influence of five anesthetic protocols on the hemogram, being GR1-ketamine 20mg / kg, IM; GR2-bupivacaine minimum dose, IM; GR3-bupivacaine maximum non-lethal dose, IM; GR4 ketamine 20mg / kg, IM + bupivacaine minimal epidural lumbosacral dose; GR5-ketamine 20mg / kg, IM + bupivacaine maximum dose non-lethal epidural lumbosacral. The blood of the animals was collected before performing the anesthesia, moment zero (M0) and after 10 (M10), 30 (M30) and 50 (M50) minutes of the accomplishment of each protocol. Significant reductions in red blood cells, hemoglobin, hematocrit, lymphocytes and total leukocytes were observed in both, the groups and at the time of collection, suggesting that anesthetic agents can generate changes in blood tissue.

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Avaliação da analgesia pós-operatória da metadona, da cetamina ou da sua associação em gatas submetidas a ovariossalpingo-histerectomia

Abstract: Avaliação da analgesia pós-operatória da metadona, da cetamina ou da sua associação em gatas submetidas a ovariossalpingo-histerectomia

Cited by 3 publications

References 21 publications

Effects of meloxicam and ketorolac in cats undergoing elective ovariohysterectomy

Effects of meloxicam and ketorolac in cats undergoing elective ovariohysterectomy

Antinociceptive and analgesic effect of continuous intravenous infusion of maropitant, lidocaine and ketamine alone or in combination in cats undergoing ovariohysterectomy

Influência de cinco protocolos anestésicos sobre o hemograma de coelhos (Oryctolagus cuniculus familiaris)

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