Acute stress induced by physical restraint can interfere with the validity of laboratory findings. Sedation could minimize such stress. However, it is not known whether sedation can affect hematologic and hemostatic parameters in cats. The purpose of this study was to evaluate hematologic and hemostatic parameters in domestic cats subjected to physical restraint in addition to one of two sedation protocols. In total, 50 cats were subjected to physical restraint and were then randomly divided into two groups of 25 animals, receiving dexmedetomidine (5 µg/kg) and butorphanol (0.3 mg/kg; DB group) or dexmedetomidine (5 µg/kg), butorphanol (0.3 mg/kg) and ketamine (3 mg/kg; DBK group). The cats were assessed for acute stress, sedation level, onset of sedation and duration of sedation. Blood samples were collected after handling and after sedation. The complete blood count (CBC), platelet count, buccal mucosal bleeding time (BMBT), whole-blood clotting time, prothrombin time (PT), activated partial thromboplastin time (aPTT) and thrombin time (TT) were determined for each sample, before and after chemical restraint. No statistically significant differences were found in the hematologic parameters. Certain hemostatic parameters (PT, aPTT and TT) were higher in the DB group (P <0.05). The onset of sedation was similar in the two groups, and the duration of sedation was longer in the DBK group. Both sedation protocols were effective for short-duration chemical restraint for blood collection from the studied cats, and no clinically relevant effects on hematologic or hemostatic parameters were detected.

RESUMO Visando avaliar os efeitos cardiovasculares e analgésicos de dois protocolos epidurais em felinos submetidos à OSH, 16 gatas mestiças, adultas, que, após indução à anestesia geral, receberam anestesia epidural (L7 -S1) com 0,26mL kg -1 de ropivacaína 0,75%, isolada (GR) ou associada a 0,1mg kg -1 morfi na (GRM). A ETCO

Avaliação da analgesia pós-operatória da metadona, da cetamina ou da sua associação em gatas submetidas a ovariossalpingo-histerectomia

The present study aimed to evaluate the effects of different sedation protocols on blood pressure and echocardiographic and electrocardiographic parameters in dogs. In total, 24 male mixed-breed dogs with a mean weight of 9.87±3.0kg were used.Animals were randomly divided into four groups (n=6), which were subjected to sedation using the following protocols: acepromazine (0.05mgkg -1 ) and butorphanol (0.3mgkg -1

The objective of this study was to investigate the echocardiographic changes during anesthesia induction in dogs sedated with acepromazine (0.05mg/kg) and butorphanol (0.3mg/kg) (AB). Twenty-four male dogs, with a mean weight of 12.40kg±3.1kg, were randomly assigned to 4 groups (n=6). Fifteen minutes after administering pre-anesthetic medication, anesthesia with diazepam (0.5mg/kg) and etomidate (1mg/kg) (group DE); diazepam (0.5mg/kg) and ketamine (3mg/kg) (group CD); propofol (4mg/kg) (group P); or ketamine (1mg/kg) and propofol (3mg/kg) (group CP) was administered to the 6 dogs in each group. Systolic blood pressure (SBP) was measured and echocardiography was performed immediately prior to the application of the sedation protocol (baseline), 15 minutes after sedation (M1), and immediately after anesthesia induction (M2). No significant differences were observed in SBP and in hemodynamic variables such as cardiac index, shortening fraction, and ejection fraction, between groups at all time points (M0, M1, and M2) evaluated. The SBP was significantly reduced after anesthetic induction in the dogs of the DE and CP groups. It can be concluded that the protocols DE and CP reduce similarly to SPB in dogs medicated with CD and P to SBP remain stable after anesthetic induction. All anesthetic induction protocols maintained a stable IC in premedicated dogs. None of the protocols evaluated promoted significant echocardiographic changes. Furthermore, the ketamine and diazepam combination had a negative impact on myocardial relaxation.