Avaliação da força de preensão em ratos Wistar, normais e obesos, submetidos à natação com sobrecarga após compressão do nervo mediano

Coradinia, Josinéia Gresele; Kakihata, Camila Mayumi Martin; Kunz, Regina Inês; Errero, Tatiane Kamada; Bonfleur, Maria Lúcia; Bertolini, Gladson Ricardo Flor

doi:10.1016/j.rbr.2014.08.003

Cited by 10 publications

(2 citation statements)

References 29 publications

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“…The evaluations were used to observe the evolution of the lesion and the form of treatment used. In each evaluation, the test was repeated three times and the mean value of the repetitions was used ( Coradinia et al, 2015 ). Other evaluations were carried out during the experiment: 2nd EV, 3rd PO, pretreatment; 3rd EV, 3rd PO, post treatment; 4th EV, 7th PO, post treatment; 5th EV, 8th PO, pretreatment; 6th EV, 14th PO, after treatment; 7th EV, 21st PO, posttreatment; 8th EV, 22nd PO, euthanasia of the animals and collection of the muscles.…”

Section: Methodsmentioning

confidence: 99%

Association of sericin and swimming on the phenotype, motor plate, and functionality of the denervated plantar muscle of Wistar rats

et al. 2018

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Physical exercise may help maintain muscle properties and functional improvement after peripheral nerve lesion, which may be enhanced by using biocompatible substances, such as sericin. The aim of this study was analyse the effect of sericin associated with swimming exercise on the phenotype, innervation, and functionality of the plantar muscle of Wistar rats. Forty randomly divided adult rats were used in five groups of eight animals: control, injury, sericin, exercise, exercise and sericin. The application of sericin was done on the spot, 100 μL, shortly after nerve compression. Three days after sciatic nerve compression, the swimming and swimming and sericin groups were submitted to physical swimming exercise for 21 days. Afterwards, the animals were euthanised and the plantar muscle was dissected and submitted to histochemical and histoenzymological techniques. The grip strength test did not show alterations in muscular functionality, and the control presented greater muscle mass in relation to the other groups, the same did not occur for muscle length. Polymorphic neuromuscular junctions were detected in the groups, although without significant morphometric alterations of the area, major and minor diameters. The percentage of type I fibres was lower in the lesion group and there was no difference in fibres IIa and IIb between groups. The area of fibres I, IIa and IIb remained constant between groups. Sericin biopolymer combined with swimming exercise did not affect plantar muscle function, submitted to experimental axonotmosis, whose contractile properties were altered by nerve injury.

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Section: Methodsmentioning

confidence: 99%

Association of sericin and swimming on the phenotype, motor plate, and functionality of the denervated plantar muscle of Wistar rats

et al. 2018

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“…However, other studies have demonstrated delays in functional recovery from this type of exercise 8 or no effect on muscle strength, 10 and because of the slow regeneration process, problems such as inadequate nerve reinsertion and nerve function inefficiency are possible, impacting directly the final result. 1 This denotes the need for research about the effect of physical exercise on nerve repair and its association with auxiliary procedural substances.…”

Section: Introductionmentioning

confidence: 98%

The Action of Sericin Protein on Initial Nerve Repair, Associated or Not With Swimming in Wistar Rats

et al. 2019

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Objective: To analyze the effects of sericin treatment, associated or not with swimming with load exercise, on initial sciatic nerve repair after compression in Wistar rats. Methods: Forty animals were divided into five groups: control, injury, injury-sericin, injury-swimming and injury-sericin-swimming. During the axonotmesis procedure, the sericin was applied to the injury-sericin and injury-sericin-swimming groups. The injury-swimming and injury-sericin-swimming groups performed the swimming with load exercise for five days, beginning on the third postoperative day (PO), and were evaluated for function, nociception and allodynia. Euthanasia was performed on the 8th PO day and fragments of the nerve were collected and prepared for quantitative and descriptive analysis in relation to the total amount of viable nerve fibers and non-viable nerve fibers, nerve fiber diameter, axon diameter and myelin sheath thickness. Results: There was no significant improvement in the sciatic functional index up to the eighth day. The Von Frey test of the surgical scar and plantar fascia indicated a reduction in pain and allodynia for the injury-swimming and injury-sericin-swimming groups. The morphological analysis presented similar characteristics in the injury-sericin, injury-swimming and injury-sericin-swimming groups, but there was a significant difference in the number of smaller non-viable nerve fibers in the injury-swimming and injury-sericin-swimming groups as compared to the others. Conclusions: Isolated sericin protein presented proinflammatory characteristics. There was improvement of allodynia and a decrease in the pain at the site of the surgical incision, possibly linked to an aquatic effect. There was no acceleration of nerve repair on the eighth day after the injury. Level of Evidence I; High quality randomized clinical trial with or without statistically significant difference, but with narrow confidence intervals.

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Experimental Periodontitis in the Potentialization of the Effects of Immobilism in the Skeletal Striated Muscle

et al. 2017

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This study aims to evaluate if ligature-induced periodontitis can potentiates the deleterious effects of immobilization in the skeletal striated muscle, contributing to the development of muscle atrophy due to disuse. Forty Wistar rats were divided into four groups: (1) Control Group (CG), (2) Periodontal Disease (PDG), (3) Immobilized (IG), and (4) Immobilized with Periodontal Disease (IPDG). Periodontal disease was induced for 30 days, with ligature method, and the immobilization was performed with cast bandage for 15 days. Prior to euthanasia, nociceptive threshold and muscular grasping force were evaluated. Afterwards, the soleus muscle was dissected and processed for sarcomere counting and morphological/morphometric analysis. For data analysis, was used the one-way ANOVA and post-test Tukey (p < 0.05). The IG and IPDG presented lower muscle weight, lower muscular grip strength, and less number of sarcomeres compared to CG. The PDG showed reduction of muscle strength and nociceptive threshold after 15 days of periodontal disease and increased connective tissue compared to CG. The IPDG presented lower muscle length and nociceptive threshold. The IG presented reduction in cross-sectional area and smaller diameter, increase in the number of nuclei and a nucleus/fiber ratio, decrease in the number of capillaries and capillary/fiber ratio, with increase in connective tissue. The IPDG had increased nucleus/fiber ratio, decreased capillaries, and increased connective tissue when compared to the IG. The IPDG presented greater muscle tissue degeneration and increased inflammatory cells compared to the other groups. Ligature-induced periodontitis potentiated the deleterious effects of immobilization of the skeletal striated muscle.

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Avaliação da força de preensão em ratos Wistar, normais e obesos, submetidos à natação com sobrecarga após compressão do nervo mediano

Abstract: The swimming exercise with overload has not been effective in promoting improvement in muscle grip strength after compression injury of the right median nerve in control and in obese-MSG rats.

Cited by 10 publications

References 29 publications

Association of sericin and swimming on the phenotype, motor plate, and functionality of the denervated plantar muscle of Wistar rats

Association of sericin and swimming on the phenotype, motor plate, and functionality of the denervated plantar muscle of Wistar rats

The Action of Sericin Protein on Initial Nerve Repair, Associated or Not With Swimming in Wistar Rats

Experimental Periodontitis in the Potentialization of the Effects of Immobilism in the Skeletal Striated Muscle

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