Avaliação Da Mesalazina Incorporada a Polímero Biodegradável No Tratamento Da Retite Actínca Em Ratos

Nunes, Vinicius Rodrigues Taranto; Araújo, Ivana Duval; Barbuto, Rafael Calvão; Vidigal, Paula Vieira Teixeira; Lima, Patrícia Gonçalves Sousa; Pereira, Márcio Tadeu; Ladeira, Luiz Carlos Duarte

doi:10.1016/j.jcol.2017.09.335

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A new formulation of mesalazine conjugated to chondroitin sulfate has recently been patched, and appears to induce a delayed response with greater effectiveness of the drug, enabling the administration of lower doses and, consequently, with fewer side side effects. 37,38…”

Section: Mesalazinementioning

confidence: 99%

Therapeutics in Radiation-induced Proctopathy: A Systematic Review

Omer

Araújo

Cruz³

et al. 2022

Journal of Coloproctology

View full text Add to dashboard Cite

Malignant neoplasms are increasingly prevalent in the daily clinical practice. Up to 61% of patients with pelvic malignancies undergo pelvic radiotherapy in different doses, which may cause intestinal damage, and the rectum is the segment most frequently affected due to its fixed position in the pelvis. Currently, there are several strategies to minimize the effects of radiation on the tissues surrounding the neoplastic site; despite those strategies, radiotherapy can still result in serious damage to organs and structures, and these injuries accompany patients throughout their lives. One of the most common damages resulting from pelvic radiotherapy is acute proctitis.The diagnosis is confirmed by visualizing the rectal mucosa through rigid or flexible rectosigmoidoscopy and colonoscopy. The objective of the present study was to review the forms of radiation-induced proctopathytherapy, and to evaluate the results of each method to propose a standardization for the treatment of this pathology. Despite the prevalence of radiation-induced proctopathy, there is no definitive standardized treatment strategy so far. The first approach can be tried with local agents, such as mesalazine and formalin. For refractory cases, control can usually be achieved with argon plasma coagulation, hyperbaric oxygen, and radiofrequency ablation therapies. Regarding the study of radiation-induced proctopathy, there is a lack of robust studies with large samples and standardized therapies to be compared. There is a lack of double-blinded, randomized controlled studies to determine a definitive standard treatment algorithm.

show abstract

Section: Mesalazinementioning

confidence: 99%