Avaliação da prevalência e do perfil epidemiológico da doença de chagas aguda entre 2014 e 2017 no estado do Pará, Brasil

Santos, Felipe Augusto Casseb dos; Braga, Ana Paula Cecília; Ferreira, Isabella Siqueira; Arêde, Mariana da Ponte Souza Prado; Baetas, Ana Leticia Figueira Diniz; Silva, Marcos Vinicius Amorim; Lima, Leila Suely Aviz

doi:10.34119/bjhrv3n4-142

Cited by 3 publications

(3 citation statements)

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“…Furthermore, in the same study the highest occurrence values were associated with ages between 20 and 59 years of age. Other studies also demonstrate a greater occurrence of the disease in males aged between 20 and 59 years (BOZELLI CE, et al, 2006;CUTRIM FSRF, et al, 2010;LIMA AJS, et al, 2021;CARDOZO EJS, et al, 2017;SILVA GG, et al, 2020;SANTOS FAC, et al, 2020), indicating that the epidemiology of the disease is strong among adult males.…”

Section: Resultsmentioning

confidence: 93%

Epidemiological Profile of Chagas Disease in Belém do Pará: A descriptive and retrospective study between 2010 and 2020

Corrêa,

Gonçalves

et al. 2024

JHS

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Section: Resultsmentioning

confidence: 93%

Epidemiological Profile of Chagas Disease in Belém do Pará: A descriptive and retrospective study between 2010 and 2020

Corrêa,

Gonçalves

et al. 2024

JHS

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“…were reported in most states, with 95% concentrated in the northern region, with 83% of the cases reported in Pará state [7].…”

Section: Introductionmentioning

confidence: 99%

Proof-of-Concept of a Novel Multiepitope Recombinant Protein for the Serodiagnosis of Patients with Chagas Disease

Machado¹,

Pereira²,

Maia³

et al. 2022

Preprint

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Background: Chagas disease is still a neglected disease considered a public health problem. Early diagnosis of cases is important to improve the prognosis of infected patients and prevent transmission. Serological tests are the method of choice for diagnosis. However, two serological tests are currently recommended to confirm positive cases. In this sense, more sensitive and specific serological tests need to be developed to overcome the problems currently faced. This study aimed to develop a new recombinant multiepitope protein for the diagnosis of Chagas disease, hereafter named rTC. Methods: The rTC was constructed based on amino acid sequences from different combinations of Trypanossoma cruzi antigens in the same polypeptide and tested in ELISA for detecting different Chagas disease. Results: rTC1 was able to discriminate between indeterminate (IND) and cardiac (CARD) cases and cross-reactive diseases, and healthy samples, with 96.6% sensitivity and 97.96% specificity, respectively. Conclusion: These data suggest a preliminary study that rTC1 has the po-tential to be tested in future studies against a larger serological panel for the diagnosis of Chagas disease.

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“…More than 10,000 people die every year from clinical complications of Chagas disease, and 75 million people are at risk of infection [ 4 , 6 ]. In Brazil, new cases were reported in most states, with 95% of them being concentrated in the northern region and 83% being reported in Pará state [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Proof of Concept of a Novel Multiepitope Recombinant Protein for the Serodiagnosis of Patients with Chagas Disease

et al. 2023

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Chagas disease remains a neglected disease that is considered to be a public health problem. The early diagnosis of cases is important to improve the prognosis of infected patients and prevent transmission. Serological tests are the method of choice for diagnosis. However, two serological tests are currently recommended to confirm positive cases. In this sense, more sensitive and specific serological tests need to be developed to overcome these current diagnosis problems. This study aimed to develop a new recombinant multiepitope protein for the diagnosis of Chagas disease, hereafter named rTC. The rTC was constructed based on amino acid sequences from different combinations of Trypanosoma cruzi antigens in the same polypeptide and tested using an enzyme-linked immunosorbent assay (ELISA) to detect different types of Chagas disease. rTC was able to discriminate between indeterminate (IND) and cardiac (CARD) cases and cross-reactive diseases, as well as healthy samples, with 98.28% sensitivity and 96.67% specificity, respectively. These data suggest that rTC has the potential to be tested in future studies against a larger serological panel for the diagnosis of Chagas disease.

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Avaliação da prevalência e do perfil epidemiológico da doença de chagas aguda entre 2014 e 2017 no estado do Pará, Brasil

Cited by 3 publications

References 0 publications

Epidemiological Profile of Chagas Disease in Belém do Pará: A descriptive and retrospective study between 2010 and 2020

Epidemiological Profile of Chagas Disease in Belém do Pará: A descriptive and retrospective study between 2010 and 2020

Proof-of-Concept of a Novel Multiepitope Recombinant Protein for the Serodiagnosis of Patients with Chagas Disease

Proof of Concept of a Novel Multiepitope Recombinant Protein for the Serodiagnosis of Patients with Chagas Disease

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