Avaliação das alterações fundoscópicas na miopia degenerativa

Brasil, Oswaldo Ferreira Moura; Brasil, Maria Vitoria Oliveira Moura; Japiassú, Ricardo Miguel; Biancardi, Ana Luiza; Souza, Débora Duarte de; Oliveira, Renato Corrêa de Souza; Moraes, Haroldo Vieira de

doi:10.1590/s0004-27492006000200013

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…PPA in most of high myopes is in the form of temporal crescentic PPA, but PPH is observed in advanced cases. 24,25 The ultrastructure of myopic crescents is similar to the β-zone of PPA, which was confirmed by the SD-OCT findings of these crescents showing complete loss of the RPE layer and a partial loss of the photoreceptor layer. As myopia develops, the axial length increases in size causing retinal stretching, thinning, and pulling of the RPE and choroid away from the optic disc.…”

Section: Discussionsupporting

confidence: 57%

Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy

Khodeiry¹,

Liu²,

Sayed³

et al. 2021

OPTH

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Purpose Peripapillary halos (PPH) are peripapillary changes observed surrounding the optic nerve head in normal eyes and eyes with different disorders. Recognizing the microstructure and mechanism of development of these halos will help clinicians understand the different associated retinal and optic nerve head pathologies. We describe the in vivo histological characteristics of PPH in birdshot chorioretinopathy (BSCR). Patients and Methods This was a prospective observational case-series in a single tertiary referral center. Six eyes of three patients with PPH associated with BSCR were determined through clinical examination, fundus photography, and fundus autofluorescence (FAF). Patients underwent swept-source optical coherence tomography (SS-OCT) imaging of the optic nerve head and peripapillary region. Results In SS-OCT B-scans across the area of PPH, we observed thinning and interruption of retinal pigment epithelium (RPE)-Bruch’s membrane complex. These halos are a circumferential form of alpha zone RPE-associated crescentic peripapillary atrophy (PPA), unlike the PPH observed with myopia and normal aging. Conclusion PPH in BSCR patients may be a sign of prior inflammatory optic neuropathy.

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Section: Discussionsupporting

confidence: 57%

Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy

Khodeiry¹,

Liu²,

Sayed³

et al. 2021

OPTH

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“…Outros distúrbios como glaucoma, conjuntivite, toxoplasmose ocular, retinopatia diabética e retinopatia hipertensiva foram encontrados em 7,8% dos pacientes usuários de lentes oculares. Os defeitos refrativos podem estar relacionados a enfermidades oftalmológicas 25 A presença de alterações fundoscópicas em pacientes com ametropias é bastante frequente e pode cursar com perda visual em graus variáveis, o que justifica a necessidade de diagnóstico e tratamento precoce 30 .…”

Section: Discussão|unclassified

Perfil clínico e epidemiológico dos pacientes atendidos em um ambulatório de oftalmologia em Vila Velha/ES

Barbosa¹,

Ferreira²,

Azevedo³

et al. 2019

RBPS

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Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia

2019

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Background Population studies suggest that genetic factors play an important role in refractive error development; however, the precise role of genetic background and the composition of the signaling pathways underlying refractive eye development remain poorly understood. Methods Here, we analyzed normal refractive development and susceptibility to form-deprivation myopia in the eight progenitor mouse strains of the Collaborative Cross (CC). We used RNA-seq to analyze gene expression in the retinae of these mice and reconstruct genetic networks and signaling pathways underlying refractive eye development. We also utilized genome-wide gene-based association analysis to identify mouse genes and pathways associated with myopia in humans. Results Genetic background strongly influenced both baseline refractive development and susceptibility to environmentally-induced myopia. Baseline refractive errors ranged from − 21.2 diopters (D) in 129S1/svlmj mice to + 22.0 D in CAST/EiJ mice and represented a continuous distribution typical of a quantitative genetic trait. The extent of induced form-deprivation myopia ranged from − 5.6 D in NZO/HILtJ mice to − 20.0 D in CAST/EiJ mice and also followed a continuous distribution. Whole-genome (RNA-seq) gene expression profiling in retinae from CC progenitor strains identified genes whose expression level correlated with either baseline refractive error or susceptibility to myopia. Expression levels of 2,302 genes correlated with the baseline refractive state of the eye, whereas 1,917 genes correlated with susceptibility to induced myopia. Genome-wide gene-based association analysis in the CREAM and UK Biobank human cohorts revealed that 985 of the above genes were associated with myopia in humans, including 847 genes which were implicated in the development of human myopia for the first time. Although the gene sets controlling baseline refractive development and those regulating susceptibility to myopia overlapped, these two processes appeared to be controlled by largely distinct sets of genes. Conclusions Comparison with data for other animal models of myopia revealed that the genes identified in this study comprise a well-defined set of retinal signaling pathways, which are highly conserved across different vertebrate species. These results identify major signaling pathways involved in refractive eye development and provide attractive targets for the development of anti-myopia drugs. Electronic supplementary material The online version of this article (10.1186/s12920-019-0560-1) contains supplementary material, which is available to authorized users.

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Avaliação das alterações fundoscópicas na miopia degenerativa

Cited by 8 publications

References 17 publications

Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy

Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy

Perfil clínico e epidemiológico dos pacientes atendidos em um ambulatório de oftalmologia em Vila Velha/ES

Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia

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