Avaliação das atividades antimicrobiana, antisséptica e esterilizante de extratos e metabólitos de Baccharis dracunculifolia D. C. e Pinus elliottii Engelm

Bernardes, Cristiane Teixeira Vilhena

doi:10.11606/t.60.2014.tde-17042015-103523

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…Enthalpy of solution measurements at 298.15 K were carried out on a LKB 2277 thermal activity monitor (TAM), equipped with a 15.0 cm 3 stainless steel cell including systems for stirring, electrical calibration, and solid sample dissolution . The calorimeter was kept in an air-conditioned room whose temperature was regulated to 295 ± 1 K. Instrument control and data acquisition were performed with the CBCAL 3.0 program . Three different types of dissolution experiments were made: (i) FBZ/MA in DMSO, (ii) MA in DMSO, and (iii) FBZ in an MA + DMSO solution.…”

Section: Methodsmentioning

confidence: 99%

A New Thermodynamically Favored Flubendazole/Maleic Acid Binary Crystal Form: Structure, Energetics, and in Silico PBPK Model-Based Investigation

Araújo

Ferreira

Bernardes

et al. 2018

Crystal Growth & Design

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The use of flubendazole (FBZ) in the treatment of lymphatic filariasis and onchocerciasis (two high incidence neglected tropical diseases) has been hampered by its poor aqueous solubility. A material consisting of binary flubendazole/maleic acid crystals (FBZ/MA), showing considerably improved solubility and dissolution rate relative to flubendazole alone, has been prepared in this work through solvent assisted mechanical grinding. The identification of FBZ/MA as a binary crystalline compound with salt character (proton transfer from MA to FBZ) relied on the combined results of powder X-ray diffraction, Raman spectroscopy, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), thermogravimetry (TG), and differential scanning calorimetry (DSC). Isothermal solution microcalorimetry studies further suggested that the direct formation of FBZ/MA from its precursors in the solid state is thermodynamically favored. A comparison of the in silico pharmacokinetic performance of the FBZ/MA with that of pure FBZ based on a rat fasted physiology model indicated that the absorption rate, mean plasma peak concentration, and absorption extension of FBZ/MA were ∼2.6 times, ∼1.4 times, and 60% larger, respectively, than those of FBZ. The results here obtained therefore suggest that the new FBZ/MA salt has a considerable potential for the development of stable and affordable pharmaceutical formulations with improved dissolution and pharmacokinetic properties. Finally, powder X-ray diffraction studies also led to the first determination of the crystal structure of FBZ.

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Section: Methodsmentioning

confidence: 99%

A New Thermodynamically Favored Flubendazole/Maleic Acid Binary Crystal Form: Structure, Energetics, and in Silico PBPK Model-Based Investigation

Araújo

Ferreira

Bernardes

et al. 2018

Crystal Growth & Design

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show abstract

“…The data that support the findings of this study are openly available in Teses USP. at https://doi.org/10.11606/ T.60.2014.tde-17042015-103523 (Bernardes, 2014).…”

Section: Conflict Of Interestmentioning

confidence: 99%

Disinfectant activities of extracts and metabolites from Baccharis dracunculifolia DC

Bernardes

Ribeiro

Carvalho

et al. 2022

Letters in Applied Microbiology

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In this study, Baccharis dracunculifolia and its metabolites were submitted to Standard Operating Procedure No. 65Á3210Á007 , developed by the National Institute for Quality Control in Health (INCQS) -Oswaldo Cruz Foundation (FIOCRUZ) and its sanitizing activity were observed. In this way, B. dracunculifolia can be a natural source with promising disinfectant capacity, which can lead to the development of new sanitizing products of natural origin, with low costs and chemically less aggressive to users based on the principles of green chemistry, resulting in a product capable of revolutionizing the application in the natural products market, with sustainable development from B. dracunculifolia.

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Avaliação das atividades antimicrobiana, antisséptica e esterilizante de extratos e metabólitos de Baccharis dracunculifolia D. C. e Pinus elliottii Engelm

Cited by 2 publications

References 39 publications

A New Thermodynamically Favored Flubendazole/Maleic Acid Binary Crystal Form: Structure, Energetics, and in Silico PBPK Model-Based Investigation

A New Thermodynamically Favored Flubendazole/Maleic Acid Binary Crystal Form: Structure, Energetics, and in Silico PBPK Model-Based Investigation

Disinfectant activities of extracts and metabolites from Baccharis dracunculifolia DC

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