Avaliação do Estresse oxidativo e Lipoperoxidação(LPO )em pacientes com diabetes mellitus tipo 2 (DM2) tratados no Hospital Universitário de Brasília (HUB)

Rosa, Erica Carine Cmpos Caldas; Santos, Renan Renato Cruz dos; Gris, Eliana Fortes; Ferreira, Eduardo Antônio; Neves, Francisco de Assis Rocha; Coêlho, Michella Soares; Amato, Angélica Amorim

doi:10.34119/bjhrv2n5-029

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…The imbalance in the regulation of ROS levels can cause several diseases, such as epilepsy [5,6], lung diseases [7], cancer [8], diabetes [9,10], Parkinson's disease [11,12], and Alzheimer's disease [13,14]. Therefore, there is a constant search for novel antioxidant molecules that can help to regulate this system.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Structural Characterization, and Property Investigation of Gallic Acid-Grafted Fungal Chitosan Conjugate

Paiva

Queiroz

Sabry

et al. 2021

JoF

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Oxidative stress is the cause of numerous diseases in humans; therefore, there has been a continuous search for novel antioxidant molecules. Fungal chitosan is an attractive molecule that has several applications (antifungal, antibacterial, anticancer and antiparasitic action) owing to its unique characteristics; however, it exhibits low antioxidant activity. The aim of this study was to obtain fungal chitosan (Chit-F) from the fungus Rhizopus arrhizus and synthesize its derivative, fungal chitosan-gallic acid (Chit-FGal), as a novel antioxidant chitosan derivative for biomedical use. A low molecular weight Chi-F (~3.0 kDa) with a degree of deacetylation of 86% was obtained from this fungus. Chit-FGal (3.0 kDa) was synthesized by an efficient free radical-mediated method using hydrogen peroxide (H2O2) and ascorbic acid. Both Chit-F and Chit-FGal showed similar copper chelating activities; however, Chit-FGal was more efficient as an antioxidant, exhibiting twice the total antioxidant capacity than Chi-F (p < 0.05). Furthermore, H2O2 (0.06 M) promoted a 50% decrease in the viabilities of the 3T3 fibroblast cells. However, this effect was abolished in the presence of Chit-FGal (0.05–0.25 mg/mL), indicating that Chit-FGal protected the cells from oxidative damage. These results suggest that Chit-FGal may be a promising agent to combat oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Preparation, Structural Characterization, and Property Investigation of Gallic Acid-Grafted Fungal Chitosan Conjugate

Paiva

Queiroz

Sabry

et al. 2021

JoF

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“…desequilíbrio entre a produção de radicais livres e as defesas antioxidantes e torna-se maior em pacientes acometidos pela DM2 (AMATO et al, 2019).…”

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Indicadores Físico-Químicos E Componentes Antioxidantes De Duas Plantas Medicinais Com Alegações Antidiabéticas Da Amazônia

Ferreira¹,

Pereira²,

Ferreira³

et al. 2023

RECIMA21

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O uso de plantas medicinais tem demonstrado benefícios aos pacientes com Diabetes Mellitus do tipo 2 (DM2), incluindo a redução do estresse oxidativo, situação comum neste grupo. Nesta perspectiva, o objetivo deste trabalho foi determinar os parametros físico-quimicos e potencial antioxidante de duas plantas medicinais com alegações antidiabéticas da Amazônia. Foram estudadas a Syzygium cumini e Myrcia sphaerocarpa, conhecidas popularmente como Jambolão e Pedra Hume caá, respectivamente. Para este fim, foram coletadas 7 amostras de Syzygium cumini e Myrcia sphaerocarpa em casas de ervas medicinais do município de Belém-PA, as quais foram submetidas a análises de pH, ºBrix, acidez, densidade, umidade, cinzas, ácido ascórbico, flavonoides, antocianinas e atividade antioxidante. Os resultados físico-químicos e de compostos antioxidantes foram apresentados através da média, desvio padrão, mínimo e máximo. Quanto aos valores encontrados, para o pH foi de 5,12 e 5,8; ºBrix 0,21 e 0,1; acidez 0,45ml NaOH/ml e 0,27ml; densidade 1,0 mg/L e 1,0 mg/L; umidade 0,72% 0,78%; cinzas 5,38% e 6,04%; 0,88% e 0,99% de ácido ascórbico; flavonoides 8,43mg/100g e 9,07mg/100g; antocianinas 6,19mg/100g e 4,87mg/100g para Syzygium cumini e Myrcia sphaerocarpa respectivamente. A atividade antioxidante foi de 0,25 para Jambolão e 0,28 para Pedra Ume Caa. Conclui-se que o Jambolão possui valores superiores nas análises de acidez titulável e antocianinas e inferiores em termos dos demais parâmetros físico-químicos e compostos com atividade antioxidantes quando comparado a Pedra Ume Caa.

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Alterations in antioxidant capacity, lipid peroxidation, and nitrite levels in type 2 diabetes

Do Nascimento Sousa da Silva,

Melo Barbosa,

Da Silva

et al. 2024

Sci Med

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Background: this case-control study delves into oxidative and antioxidant markers, including Total Antioxidant Capacity (TAC), lipid peroxidation, and nitrites, alongside glucose levels in individuals with hyperglycemia due to type 2 diabetes mellitus (T2DM) in comparison to their healthy counterparts. Furthermore, the study explores the impact of glucose on these variables. Methods: twenty patients diagnosed with T2DM and hyperglycemia were included, along with a control group of 20 healthy subjects (Control Group – CG). Glucose levels, as well as oxidative markers (malondialdehyde and nitrites) and antioxidants, were assessed in the blood plasma of each participant. To ascertain statistically significant differences between the studied variables across groups, Student t-test or Mann–Whitney tests were employed. Pearson’s Linear Correlation test was utilized to evaluate associations between the variables. Results: glucose and TAC levels exhibited significant elevation in the T2DM group compared to the CG. In T2DM patients, malondialdehyde and nitrites demonstrated reduced levels (1.83±0.84 µM/L and 29.5±16.6 µmol/L, respectively) in contrast to the CG (4.00±1.11 µM/L and 82.9±29.2 µmol/L, respectively), with both parameters showing a robust positive correlation (p = 0.0002). Conclusions: individuals with diabetes manifest alterations in the redox state, characterized by diminished lipid peroxidation and nitrite levels, suggesting disruptions in the constitutive pathway for nitric oxide production. This underscores the intricate interplay between oxidative stress, antioxidants, and glucose metabolism.

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Avaliação do Estresse oxidativo e Lipoperoxidação(LPO )em pacientes com diabetes mellitus tipo 2 (DM2) tratados no Hospital Universitário de Brasília (HUB)

Cited by 4 publications

References 6 publications

Preparation, Structural Characterization, and Property Investigation of Gallic Acid-Grafted Fungal Chitosan Conjugate

Preparation, Structural Characterization, and Property Investigation of Gallic Acid-Grafted Fungal Chitosan Conjugate

Indicadores Físico-Químicos E Componentes Antioxidantes De Duas Plantas Medicinais Com Alegações Antidiabéticas Da Amazônia

Alterations in antioxidant capacity, lipid peroxidation, and nitrite levels in type 2 diabetes

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