Avances en el diagnóstico, fisiopatología y tratamiento de la colitis ulcerativa crónica inespecífica

Gonzalez-Altamirano, Jorge; Paz-Delgadillo, Jonathan; Bosques-Padilla, Francisco

doi:10.1016/j.rgmx.2013.06.033

Cited by 1 publication

(1 citation statement)

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“…The diagnosis of UC was made according to previously established international criteria based on clinical, endoscopic, histopathologic, and radiographic findings. 19 Intravenous corticosteroid-resistant UC is defined as a lack of response to an adequate dosage of cortico-steroids within 5 to 7 days. 20 Patients were eligible for inclusion in this study if they had been hospitalized between January 1995 and May 2012 for treatment of acute UC that was refractory to intravenous hydrocortisone, and they were subsequently treated with either intravenous cyclosporine or infliximab.…”

Section: Methodsmentioning

confidence: 99%

Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study

Kim

Park

et al. 2015

Gut Liver

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Background/AimsIn patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab.MethodsBetween January 1995 and May 2012, the medical records of 43 patients with corticosteroid-refractory UC who received either infliximab or cyclosporine as a rescue therapy at a tertiary care hospital in Korea were reviewed.ResultsAmong the 43 patients, 10 underwent rescue therapy with cyclosporine and the remaining 33 patients received infliximab. A follow-up of 12 months was completed for all patients. The colectomy rate at 12 months was 30% and 3% in the cyclosporine and the infliximab groups, respectively (p=0.034). However, the Cox proportional hazard model indicated that the treatment of rescue therapy was not an independent associate factor for preventing colectomy (p=0.164). In the subgroup analysis, infliximab with azathioprine was superior to cyclosporine for preventing colectomy (hazard ratio of infliximab with azathioprine compared with cyclosporine only, 0.073; 95% confidence interval, 0.008 to 0.629).ConclusionsNo difference between infliximab and cyclosporine with respect to preventing colectomy was noted. However, infliximab with azathioprine may be more effective than cyclosporine alone for preventing colectomy.

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Section: Methodsmentioning

confidence: 99%