Avascular necrosis of bone with hemiparesis: a rare presentation of primary antiphospholipid antibody syndrome

Abstract

Vascular complications are well known manifestations of primary antiphospholipid antibody syndrome but the concurrent existence of avascular necrosis of bone and stroke due to vasculitic infarct is a very rare presentation. We report a case of a middle-aged man who presented with right knee pain and left hemiparesis and was subsequently diagnosed to have primary antiphospholipid antibody syndrome.

Salmonella osteomyelitis complicating aseptic osteonecrosis: Don’t forget about the antiphospholipid syndrome

“…The avascular necrosis of bone is a significant threat to APL patients. It may even be among the presenting symptoms 4 . The prevalence rates ranged widely between 0.9% and 20% 5,6 …”

“…It may even be among the presenting symptoms. 4 The prevalence rates ranged widely between 0.9% and 20%. 5,6 The literature suggests that the cause of the clinical manifestations of APS is mostly the hypercoagulable state induced by these antibodies bound to various phospholipids on components of the coagulation system.…”

Antiphospholipid (Hughes) syndrome: insights for orthopedics

“…Indeed, the prevalence of arthralgia and arthritis in major studies leans towards certain patient characteristics such as female gender and disease secondary to systemic lupus erythematosus (SLE). 3,4 It is now clearer than ever that APS patients are at risk of avascular necrosis of bone (AVN); it may even be among the presenting symptoms 5 ( Figure 1). While the prevalence rates ranged widely between 0.9% 3 and 20%, 6 magnetic resonance imaging (MRI) clearly showed AVN in these patients.…”

“…It is now clearer than ever that APS patients are at risk of avascular necrosis of bone (AVN); it may even be among the presenting symptoms 5 (Figure 1). While the prevalence rates ranged widely between 0.9% 3 and 20%, 6 magnetic resonance imaging (MRI) clearly showed AVN in these patients.…”