Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication

Táng, Shuāng; Li, Jie; Chang, Yung-Fu; Lin, Wencheng

doi:10.3389/fimmu.2022.907287

Cited by 9 publications

(11 citation statements)

References 86 publications

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“…In previous studies, Itgb1 was highly expressed in glioma, osteosarcoma, and bone marrow mesenchymal stem cells.Itgb1 is a member of the ITG family [21,22], which is closely associated with apoptosis. Itgb1 enhances the radiation resistance of non-small cell lung cancer cells by regulating the DNA damage response [23]and YAP1-induced epithelial-mesenchymal transition [24,25]. Itgb1 mediates the Notch signaling pathway [26,27], which affects the proliferation of glioma cells, and molecular DNA mutations in the Notch signaling pathway are highly correlated with malignant tumorigenesis [28,29].…”

Section: Discussionmentioning

confidence: 99%

Identification of Itgb1 as a critical gene for radiation-induced injury by bioinformatic analysis combined with experimental verification

Zhang

Xiao²,

et al. 2023

Preprint

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Radiation injury is a common side effect of nuclear and radiation accidents as well as clinical oncologic radiotherapy. The organism undergoes a series of pathological responses after irradiation, especially in the short term, accompanied by an intense inflammatory storm [1], and effective targets for intervention have not been identified [2]. In this study, we screened differential genes in gene microarray data from the GEO database and then identified the core gene Itgb1 by enrichment analysis. Subsequently, the expression of Itgb1 was knocked down by siRNA interference and was functionally blocked by RGD, a Itgb1 inhibitor. Next, the proliferation and apoptosis of irradiated cells was detected, and injury of lung tissues and hemopoietic system were also investigated. As a result, knockdown of Itgb1 protected pulmonary epithelial cells and blood cell from irradiation, and RGD remitted the irradiation-induced lung injury and hematopoietic injury. This study suggests that Itgb1 plays a key role in radiation injury and provides new ideas for the prevention and treatment of radiation therapy.

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Section: Discussionmentioning

confidence: 99%

Identification of Itgb1 as a critical gene for radiation-induced injury by bioinformatic analysis combined with experimental verification

Zhang

Xiao²,

et al. 2023

Preprint

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“…It is well known that viruses associate with many host factors to support propagation themselves [17][18][19][20][21], and HBV is no exception. Here, we show that the HBV core protein interacts with the MCM2-7 complex, which has a crucial role in host DNA replication as a DNA helicase [22][23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Identification of the Interaction between Minichromosome Maintenance Proteins and the Core Protein of Hepatitis B Virus

Ohsaki

Wada

et al. 2023

CIMB

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Chronic HBV infection is a major cause of cirrhosis and hepatocellular carcinoma. Finding host factors involved in the viral life cycle and elucidating their mechanisms is essential for developing innovative strategies for treating HBV. The HBV core protein has pleiotropic roles in HBV replication; thus, finding the interactions between the core protein and host factors is important in clarifying the mechanism of viral infection and proliferation. Recent studies have revealed that core proteins are involved in cccDNA formation, transcriptional regulation, and RNA metabolism, in addition to their primary functions of capsid formation and pgRNA packaging. Here, we report the interaction of the core protein with MCMs, which have an essential role in host DNA replication. The knockdown of MCM2 led to increased viral replication during infection, suggesting that MCM2 serves as a restriction factor for HBV proliferation. This study opens the possibility of elucidating the relationship between core proteins and host factors and their function in viral proliferation.

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“…Exogenous ASLVs are transmitted horizontally from one individual to another or vertically (congenitally) from progenitor to offspring prior to birth (Figure 1). Infected chickens shed viral particles in their fluids, mainly feces, and horizontal transmission can be direct or indirect through contaminated fomites [33]. Hens can transfer both viruses and specific antibodies to their progeny.…”

Section: Routes Of Transmission: Horizontal Versus Verticalmentioning

confidence: 99%

Avian Leukosis: Will We Be Able to Get Rid of It?

Fandiño,

Gomez-Lucia,

Benítez

et al. 2023

Animals

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Avian leukosis viruses (ALVs) have been virtually eradicated from commercial poultry. However, some niches remain as pockets from which this group of viruses may reemerge and induce economic losses. Such is the case of fancy, hobby, backyard chickens and indigenous or native breeds, which are not as strictly inspected as commercial poultry and which have been found to harbor ALVs. In addition, the genome of both poultry and of several gamebird species contain endogenous retroviral sequences. Circumstances that support keeping up surveillance include the detection of several ALV natural recombinants between exogenous and endogenous ALV-related sequences which, combined with the well-known ability of retroviruses to mutate, facilitate the emergence of escape mutants. The subgroup most prevalent nowadays, ALV-J, has emerged as a multi-recombinant which uses a different receptor from the previously known subgroups, greatly increasing its cell tropism and pathogenicity and making it more transmissible. In this review we describe the ALVs, their different subgroups and which receptor they use to infect the cell, their routes of transmission and their presence in different bird collectivities, and the immune response against them. We analyze the different systems to control them, from vaccination to the progress made editing the bird genome to generate mutated ALV receptors or selecting certain haplotypes.

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Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication

Cited by 9 publications

References 86 publications

Identification of Itgb1 as a critical gene for radiation-induced injury by bioinformatic analysis combined with experimental verification

Identification of Itgb1 as a critical gene for radiation-induced injury by bioinformatic analysis combined with experimental verification

Identification of the Interaction between Minichromosome Maintenance Proteins and the Core Protein of Hepatitis B Virus

Avian Leukosis: Will We Be Able to Get Rid of It?

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