Avoparcin, a new macrocyclic antibiotic chiral run buffer additive for capillary electrophoresis

Ekborg-Ott, K. Helen; Zientara, Gina A.; Schneiderheinze, Jeffrey M.; Gahm, Kyung H.; Armstrong, Daniel W.

doi:10.1002/(sici)1522-2683(19990801)20:12<2438::aid-elps2438>3.0.co;2-c

Cited by 32 publications

(11 citation statements)

References 33 publications

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“…Macrocyclic antibiotics have been shown to be very effective chiral selectors both for HPLC and CE. The glycopeptides vancomycin [131], teicoplanin [132], ristocetin A [133] and avoparcin [134] as well as the polypeptide thiostrepton [131] and the ansamycin rifamycin B [131] have been used for the preparation of chiral HPLC phases. A comprehensive review on the application of macrocyclic antibiotics as chiral selectors for both HPLC and CE was recently given by Ward and Fattis [135].…”

Section: Direct Methodsmentioning

confidence: 99%

“…Ristocetin A was shown to be applicable to a broad spectrum of compounds [133] using either normal-phase, polar organic or reversed-phase mode. Avoparcin, has recently been introduced as a chiral selector and was demonstrated to have chiral recognition properties complementary to the other macrocyclic antibiotics [134]. Recently, a new CSP containing the macrocyclic glycopeptide A-40 926 was introduced and compared regarding its chiral recognition ability with the teicoplanin phase [142,143].…”

Section: Direct Methodsmentioning

confidence: 99%

“…Thus, the positively charged selector moves to the cathode, clearing the detection window, and the analytes can be detected without interferences at the anodic side. Further macrocyclic antibiotics of the glycopeptide type investigated as chiral selectors are A 82846B [404], LY307599 [405], Actaplanin A [406], Avoparcin [407], Hepta-tyr [408] and A 35512B [409].…”

Section: Neutral CD Derivatives a Great Variety Of Neutral Derivativmentioning

confidence: 99%

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Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

226

135

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This review gives a survey of different chiral separation principles and their use in high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques. The mechanisms of the different separation principles are briefly discussed and some selected applications are shown.

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Section: Direct Methodsmentioning

confidence: 99%

Section: Direct Methodsmentioning

confidence: 99%

Section: Neutral CD Derivatives a Great Variety Of Neutral Derivativmentioning

confidence: 99%

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Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

226

135

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“…However, in the case of surface-active antibiotics (namely, teicoplanin, rifamycin B and rifamycin SV), no enantioresolution was observed in the absence of organic modifier. It was postulated that addition of organic modifier is mandatory to prevent their self-aggregation in solution Ekborg-Ott et al, 1999;Gasper et al, 1996).…”

Section: Nature and Concentration Of Organic Modifiermentioning

confidence: 99%

“…two primary and one secondary) and therefore tends to strongly absorb on the capillary wall. Therefore, sometimes its application is found to create problem with CE instrument (Ekborg-Ott et al, 1999).…”

Section: Adsorption Of Css On Capillary Wallmentioning

confidence: 99%

Application of antibiotics as chiral selectors for capillary electrophoretic enantioseparation of pharmaceuticals: a review

Dixit

Park

2013

Biomedical Chromatography

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Recent years have witnessed several new trends in chiral separation, for example, the enantiorecognition ability of several new antibiotics has been explored using capillary electrophoresis (CE) prior to HPLC; antibiotics have been employed as chiral selectors (CSs) in a nonaqueous CE (NACE) mode; and several new detection techniques (namely, capacitively coupled contactless conductivity detection) have been used in combination with CE for quantification of enantiomers. On account of these emerging trends, this article aims to review the application of various classes of antibiotics for CE enantioseparation of pharmaceuticals. A detailed account of the basic factors affecting enantioseparation, certain limitations of antibiotics as CSs and strategies to mitigate them, and advantages of NACE while using antibiotics as CSs has also been presented.

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Recent progress in chiral separation principles in capillary electrophoresis

2000

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This review summarizes recent developments in the field of chiral separations by electromigration techniques including capillary zone electrophoresis (CZE), capillary gel electrophoresis (CGE), isotachophoresis (ITP), electrokinetic chromatography (EKC), and capillary electrochromatography (CEC). This overview focuses on the development of new chiral selectors and the introduction of new techniques rather than applications of already established selectors and methods. The mechanisms of the different chiral separation principles are discussed.

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Avoparcin, a new macrocyclic antibiotic chiral run buffer additive for capillary electrophoresis

Cited by 32 publications

References 33 publications

Chiral separation by chromatographic and electromigration techniques. A Review

Chiral separation by chromatographic and electromigration techniques. A Review

Application of antibiotics as chiral selectors for capillary electrophoretic enantioseparation of pharmaceuticals: a review

Recent progress in chiral separation principles in capillary electrophoresis

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