Awaking, exercising, sitting, walking and extubating: moving on the paradigms for mechanically ventilated patients

Park, Marcelo; Pires-Neto, Ruy Camargo; Nassar, Antônio Paulo

doi:10.5935/0103-507x.20140030

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Alveolar surfactants are responsible for a range of biological responses, which could prevent the activation of inflammatory cells and inhibit the release of inflammation-related cytokines, thereby modulating the immune response. The quantity and quality of alveolar surfactants are known to change significantly during MV; this results in the inactivation of inflammatory biological responses, thereby facilitating the advancement of VILI (Kneyber et al, 2014;Park et al, 2014). Therefore, current research is focusing on identifying the factors that could regulate alveolar surfactants and improve VILI.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of interleukin-10 and recombinant human keratinocyte growth factor-2 on ventilation-induced lung injury in rats

Wu¹,

Xiong²,

Xiong³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. A rat model of ventilation-induced lung injury (VILI) during anesthesia was generated to investigate the potential role and possible mechanism of interleukin-10 (IL-10) and recombinant human keratinocyte growth factor-2 (rhKGF-2) in protecting anesthetized rats against VILI. A total of 50 male SD rats were randomly divided into 5 groups (N = 10 each): control, VILI, IL-10, rhKGF-2, and IL-10 + rhKGF-2. The VILI (model) group was generated via ventilation, with a tidal volume of 20 mL/kg. Rats in the IL-10 and rhKGF-2 groups received 8 mg/kg IL-10 and 5 mg/kg rhKGF-2, respectively, prior to ventilation. The rats in the IL-10 + rhKGF-2 group received both 8 mg/ kg IL-10 and 5 mg/kg rhKGF-2 72 h before ventilation. The total number of nucleated cells and neutrophils in the bronchial alveolar lavage fluid was quantified, and the pathological changes in the pulmonary tissues examined by hematoxylin and eosin staining. The transcript and protein levels of surfactant protein C (SP-C) in lung tissues were detected by real-time polymerase chain reaction and western blot analyses. The

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Section: Introductionmentioning

confidence: 99%

Protective effect of interleukin-10 and recombinant human keratinocyte growth factor-2 on ventilation-induced lung injury in rats

Wu¹,

Xiong²,

Xiong³

et al. 2015

Genet. Mol. Res.

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Functional evolution of critically ill patients undergoing an early rehabilitation protocol

Murakami¹,

Yamaguti²,

Onoue³

et al. 2015

Revista Brasileira De Terapia Intensiva

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ObjectiveEvaluation of the functional outcomes of patients undergoing an early rehabilitation protocol for critically ill patients from admission to discharge from the intensive care unit.MethodsA retrospective cross-sectional study was conducted that included 463 adult patients with clinical and/or surgical diagnosis undergoing an early rehabilitation protocol. The overall muscle strength was evaluated at admission to the intensive care unit using the Medical Research Council scale. Patients were allocated to one of four intervention plans according to the Medical Research Council score, the suitability of the plan’s parameters, and the increasing scale of the plan expressing improved functional status. Uncooperative patients were allocated to intervention plans based on their functional status. The overall muscle strength and/or functional status were reevaluated upon discharge from the intensive care unit by comparison between the Intervention Plans upon admission (Planinitial) and discharge (Planfinal). Patients were classified into three groups according to the improvement of their functional status or not: responsive 1 (Planfinal > Planinitial), responsive 2 (Planfinal = Planinitial) and unresponsive (Planfinal < Planinitial).ResultsIn total, 432 (93.3%) of 463 patients undergoing the protocol responded positively to the intervention strategy, showing maintenance and/or improvement of the initial functional status. Clinical patients classified as unresponsive were older (74.3 ± 15.1 years of age; p = 0.03) and had longer lengths of intensive care unit (11.6 ± 14.2 days; p = 0.047) and hospital (34.5 ± 34.1 days; p = 0.002) stays.ConclusionThe maintenance and/or improvement of the admission functional status were associated with shorter lengths of intensive care unit and hospital stays. The results suggest that the type of diagnosis, clinical or surgical, fails to define the positive response to an early rehabilitation protocol.

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Awaking, exercising, sitting, walking and extubating: moving on the paradigms for mechanically ventilated patients

Cited by 2 publications

References 15 publications

Protective effect of interleukin-10 and recombinant human keratinocyte growth factor-2 on ventilation-induced lung injury in rats

Protective effect of interleukin-10 and recombinant human keratinocyte growth factor-2 on ventilation-induced lung injury in rats

Functional evolution of critically ill patients undergoing an early rehabilitation protocol

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