Teachers should be trained in resuscitation techniques as they often teach or perform CPR on children during an emergency in the school setting. Still, it was rarely mentioned in the literature, especially in the Malaysian school setting. This study aims to investigate secondary school teachers’ readiness (knowledge, attitude, and willingness) to teach and perform CPR. Through stratified random sampling, 308 secondary school teachers from eleven schools across Petaling Perdana district, Selangor, responded to an online survey. The results showed a low passing rate in CPR knowledge (1.9%), while 84.1% refused to participate in any CPR courses. However, a higher proportion of teachers were willing to teach CPR courses (62.3%). A total of 72.1% of respondents stated that there is no automated external defibrillator (AED) within their school compound. More than half (53.0%) were unwilling to use the AED machine during an emergency. Nevertheless, more than half (65.0%) were willing to start CPR if they witnessed a cardiac arrest incident. A one-way MANOVA analysis showed that there was a significant effect of the courses taught among the secondary school teachers on the knowledge, F (4, 303) = 4.374; p < .05, attitude, F (4, 303) = 5.2; p < .05, and willingness, F (4, 303) = 5.236; p < .05. The teachers who taught language subjects reported significantly higher knowledge (M = 16.50) than others, while those teaching applied sciences and technology reported significantly higher attitudes (M = 9.28) and willingness (M = 31.56) than those teaching humanities and arts, respectively. Secondary school teachers are aware of the importance of CPR, and there is a need to explore how to integrate CPR into the current educational curriculum.