2020
DOI: 10.1080/13607863.2020.1711859
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Awareness in severe Alzheimer’s disease: a systematic review

Abstract: Objective: There is limited understanding about how people in the severe stages of Alzheimer's disease (AD) experience and demonstrate awareness. We synthesised all available evidence with the aim of understanding how awareness is preserved or impaired in severe AD and what evidence there is for different levels of awareness according to the levels of awareness framework. Method: A systematic search of the following databases: Embase, PsycINFO, MEDLINE and Web of Science was carried out. A narrative synthesis … Show more

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Cited by 17 publications
(25 citation statements)
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“…Indeed, the widespread brain damage occurring in the advanced stages of AD compromises the information transfer and the anterograde memory, among other functions. Generally, this results in the patients having a very altered perception of their current experience, reduced awareness of what is happening in their surroundings, and to their state of health (O'Shaughnessy et al, 2021 ). At the late stage of the disease, the degradation is so massive that it affects not only the awareness of being ill but also the self-knowledge and sense of identity (Addis and Tippett, 2004 ).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, the widespread brain damage occurring in the advanced stages of AD compromises the information transfer and the anterograde memory, among other functions. Generally, this results in the patients having a very altered perception of their current experience, reduced awareness of what is happening in their surroundings, and to their state of health (O'Shaughnessy et al, 2021 ). At the late stage of the disease, the degradation is so massive that it affects not only the awareness of being ill but also the self-knowledge and sense of identity (Addis and Tippett, 2004 ).…”
Section: Discussionmentioning
confidence: 99%
“… 9 Studies generally suggest that awareness at this level becomes increasingly impaired with progression of AD; however, some individuals with severe AD may still show some limited awareness of their cognitive decline. 9 , 10 , 11 , 12 , 13 Anosognosia is related to other overlapping features of higher‐level awareness and cognitive function affected by AD, and to the integration of these processes (see Box 2 ). A component of higher‐level awareness associated with episodic memory is autonoetic consciousness.…”
Section: Ad Leads To Dysfunction Of Awareness and Arousalmentioning
confidence: 99%
“…While there is variability in higher‐level social awareness in early AD, this appears to decline as dementia progresses into the moderate–severe stages, 34 , 48 although inferences made from observations suggest some people with severe AD may retain some ability to empathize with others. 13 …”
Section: Ad Leads To Dysfunction Of Awareness and Arousalmentioning
confidence: 99%
“…Alzheimer's disease (AD) is a progressive neurodegenerative disease that seriously endangers the health of middle‐aged and elderly people. With the aging of the population, the number of people suffering from AD is increasing rapidly, which is estimated to increase three times by 2050, and brings heavy burden to families and societies (Frankel et al., 2019; O'Shaughnessy et al., 2020). The characteristic pathological signs of AD are senile plaques formed by β‐amyloid (Aβ) deposition and neurofibrillary tangles formed by tau protein hyperphosphorylation, as well as neuron loss accompanied by glial cell proliferation.…”
Section: Introductionmentioning
confidence: 99%