Various interventions, including innovative technologies, have been used to solve problems. Over the years, the Nigerian government has introduced a good healthcare delivery system, including providing quality, efficacious and affordable drugs. The study used a qualitative design method adopting a focus group discussion approach. The selected states for the study are Lagos, Kano, Anambra and FCT Abuja. The study population comprised NAFDAC stakeholders who are dealers in pharmaceutical products or Marketing Authorization Holders (MAHs) of medicines, Consumers and Policymakers. The focus group participants were selected based on convenience sampling. The interventions highlighted were Mobile Authentication Services (MAS), on-the-spot checks on drugs through a TruScan, Black-Eye and Radio Frequency Identification Devices (RFID). The respondents also highlighted using NAFDAC registration numbers and holograms as important ways of checking the features of medicine before using it. The participants also highlighted the lack of public awareness about these interventions and the need for proper regulation and enforcement of laws against the sale and distribution of fake drugs as challenges that hinder the successful development and implementation of interventions against fake and counterfeit drugs. The participants suggested KYC measures to address issues within the supply chain to evaluate the effectiveness of their current strategies. Regular meetings, advocacy efforts, and educational workshops are recommended to raise awareness and educate stakeholders about their roles and responsibilities in pursuit of addressing the challenges related to counterfeit drug interventions. Keywords: Focus group discussion (FGD), Investigation, Intervention, Counterfeit, Technology.