The biologic process of osseointegration (bone to implant interface), in which the implant forms an intimate relationship with the bone, provides the foundation for modern dental implants. Osseointegration necessitates a varying length of healing time. Despite the high success and survival rates of dental implants, problems do occur, necessitating ongoing periodontal and prosthodontic care. This failure frequently results in "peri-implantitis," which affects the soft and hard tissues surrounding the osseointegrated implants, resulting in the formation of a peri implant pocket and bone loss. Decontamination is a difficult feature of surgical regenerative therapy for peri-implantitis that has an impact on its success. Because microbial biofilms play such a significant part in the aetiology of peri-implant illnesses, it has long been assumed that eliminating microbial pathogens would be beneficial.