Axial length decrease accompanying successful glaucoma filtration surgery

Cashwell, L. Frank; Martin, Claude

doi:10.1016/s0161-6420(99)90531-6

Cited by 86 publications

(99 citation statements)

References 7 publications

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“…A decrease in axial eye length due to lowered intraocular pressure has been shown in several previous studies [19][20][21][22][23] To our knowledge, this is the first study to demonstrate this effect after systemic administration of acetazolamide and the first to investigate the difference in rigidity between healthy and glaucomatous eyes in vivo. The resulting axial eye length decrease per mmHg IOP reduction was smaller for the glaucomatous eyes than for the healthy ones, suggesting that glaucomatous eyes are more rigid.…”

Section: Discussionsupporting

confidence: 64%

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Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls

Ebneter

Wagels

Zinkernagel

2008

Eye

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Purpose To determine in vivo whether a pharmacologically induced change in intraocular pressure (IOP) leads to measurable changes in axial eye length and whether there is a difference between glaucoma patients and control subjects. Methods 42 subjects (19 patients with primary open angle glaucoma and 23 control patients matched for age and gender) underwent axial eye length measurement using partial coherence laser interferometry and measurement of IOP using dynamic contour tonometry before and 2 h after oral intake of 500 mg acetazolamide. Student's t-test was used to compare differences in the means. Results An identical drop in IOP was induced in both the glaucoma (mean ± SEM: 2.90 ± 0.44 mmHg, n ¼ 19) and the control group (mean±SEM: 3.17±0.32 mmHg, n ¼ 23). The change in axial eye length was significantly smaller (P ¼ 0.026) in the glaucoma group (mean±SEM: À14.2±3.2 lm, n ¼ 19) compared with the control group (mean ± SEM: À23.0 ± 2.98 lm, n ¼ 23). Conclusions Our results strongly suggest that the ocular rigidity is increased in patients with established glaucoma in comparison to control subjects. Ocular rigidity could play a role in the pathogenesis and pathophysiology of glaucoma. Determination of ocular rigidity could be helpful in detection of glaucoma.

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Section: Discussionsupporting

confidence: 64%

“…[16][17][18] Several studies have shown a decrease of axial eye length with lowered intraocular pressure after trabeculectomy. [19][20][21][22] A recent study by Leydolt et al 23 measured the change of axial eye length after mechanically inducing intraocular pressure elevation.…”

Section: à3mentioning

confidence: 99%

Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls

Ebneter

Wagels

Zinkernagel

2008

Eye

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“…Several studies have shown a decrease of axial eye length with lowered intraocular pressure, as seen after trabeculectomy [16][17][18] or after pharmacological treatment. 3 mmHg).…”

Section: Discussionmentioning

confidence: 99%

Effects of change in intraocular pressure on axial eye length and lens position

Leydolt

Findl

Drexler

2007

Eye

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Purpose To quantify the biometric changes of ocular dimensions with mechanical elevation of intraocular pressure (IOP) in vivo, to get a better understanding of the elastic properties of the human ocular structures that may play a role in the pathogenesis of various diseases such as myopia or glaucoma. Methods Changes in IOP were induced by a suction cup in 18 eyes under cycloplegia. Axial eye length (AEL) and anterior chamber depth (ACD) were measured with non-invasive laser interferometry during elevation of the IOP 10 and 20 mmHg over baseline values and after a 10-min resting period. Results IOP elevation of 10 and 20 mmHg respectively caused a significant increase of AEL of 23 lm (95% confidence interval: 14-34 lm) and 39 lm (confidence interval (CI): 28-51 lm). After mechanical oculopression, which resulted in an IOP reduction of -5.1 mmHg (CI: À6.3 to À4.0 mmHg) vs baseline, a significant shortening of À7 lm (CI: À13 to 0 lm) was observed. The change in AEL correlated with the change in IOP (r ¼ 0.66, P ¼ 0.005). Furthermore, a significant increase in ACD of 30 lm (CI: 24-36 lm) was detected with IOP reduction after oculopression, but no change was seen during IOP elevation. Conclusions Biometric changes of the human eye as a response to IOP changes were assessed in vivo. The correlation between change in AEL and IOP found emphasizes the need of in vivo ocular rigidity measurements in the human eye.

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“…[1][2][3] Other ocular changes after trabeculectomy, such as axial length (AL) decrease and improvement of ocular blood flow have also been reported previously. 4,5 As choroidal thickness (CT) is likely a dynamic parameter that is influenced by oscillations in IOP, a large decrease in IOP due to trabeculectomy might lead to significant CT changes. However, there has been no quantitative study on CT changes after large decreases in IOP.…”

Section: Introductionmentioning

confidence: 99%

Changes in choroidal thickness, axial length, and ocular perfusion pressure accompanying successful glaucoma filtration surgery

Kara¹,

Baz

Altan

et al. 2013

Eye

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Purpose To investigate the changes in choroidal thickness (CT), axial length (AL), and ocular perfusion pressure (OPP) accompanying intraocular pressure (IOP) reduction after trabeculectomy. Methods Thirty-nine eyes of 39 patients with primary open-angle glaucoma uncontrolled by medical therapy were included in this prospective and interventional study. All patients underwent a fornix-based trabeculectomy. The CT was measured by enhanced depth imaging-optical coherence tomography. IOP, AL, and systolic/ diastolic blood pressure were also measured, and OPP was calculated. All measurements were performed at baseline and 1 month after surgery. Results The mean IOP was 25.0 ± 5.8 mm Hg at baseline and 11.7 ± 2.6 mm Hg after trabeculectomy (Po0.001), and the mean subfoveal CT was 295±84 mm Hg at baseline and 331±82 mm Hg after trabeculectomy (Po0.001). The mean AL was 23.64 ± 0.98 mm at baseline and 23.54 ± 0.96 mm after trabeculectomy (Po0.001), whereas the mean OPP was 38.8 ± 6.2 mm Hg preoperatively, and 51.1 ± 7.3 mm Hg postoperatively (Po0.001). The change in CT negatively correlated with the change in IOP (r ¼ À 0.785, Po0.001) and AL (r ¼ À 0.693, Po0.001), whereas it positively correlated with the change in OPP (r ¼ 0.418, P ¼ 0.008). Conclusion These results suggest that the large IOP decrease following trabeculectomy causes choroidal thickening.In addition, CT changes are associated with IOP and AL reduction as well as OPP increase.

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Axial length decrease accompanying successful glaucoma filtration surgery

Cited by 86 publications

References 7 publications

Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls

Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls

Effects of change in intraocular pressure on axial eye length and lens position

Changes in choroidal thickness, axial length, and ocular perfusion pressure accompanying successful glaucoma filtration surgery

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