Axillary syringomas mimicking Fox–Fordyce disease

Roga, Gillian; Bhat, Ishwar

doi:10.4103/2229-5178.164476

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…Even though they appear as brown or pink papules <4 mm in size, a biopsy is usually needed to distinguish syringomas from FFD 46 . Small collections of epithelial cells with central ducts in the superficial dermis are notably seen in syringomas 46 . Very rarely, acanthosis nigricans involving the axillae can appear like FFD, but the former appears as hyperpigmented velvety plaques with a granular appearance.…”

Section: Discussionmentioning

confidence: 99%

“…Axillary syringomas are another dermatological manifestation mimicking FFD. Even though they appear as brown or pink papules <4 mm in size, a biopsy is usually needed to distinguish syringomas from FFD 46 . Small collections of epithelial cells with central ducts in the superficial dermis are notably seen in syringomas 46 .…”

Section: Discussionmentioning

confidence: 99%

“…46 Small collections of epithelial cells with central ducts in the superficial dermis are notably seen in syringomas. 46 Very rarely, acanthosis nigricans involving the axillae can appear like FFD, but the former appears as hyperpigmented velvety plaques with a granular appearance. GLPLS, DD, and HHD are infrequent dermatologic manifestations which have been mistaken with FFD.…”

Section: Calcipotriol and Betamethasonementioning

confidence: 99%

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Pathophysiology, clinical findings, and management of Fox‐Fordyce disease: A systematic review

Salloum

Bouferraa

Bazzi

et al. 2021

J of Cosmetic Dermatology

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Background: Fox-Fordyce (FFD), also known as apocrine military, is an uncommon chronic inflammation of the apocrine sweat glands. It is characterized by pruritic, papular eruptions in apocrine-gland-bearing regions. FFD was described a century ago, but the exact pathogenesis of the disease and the management are not well understood. Aims:This paper provides a wide understanding of the pathophysiology, clinical findings, and management of Fox-Fordyce disease. Its aim is to help the physician to diagnose and manage this entity accordingly.Methods: A research was done using PubMed database on 12 April 12, 2020, and in order to retrieve all case reports, case series, cohort studies, randomized, and nonrandomized clinical trials were included describing FFD among patients.Results: A total of 43 articles and 68 patients were included in the study. The majority of patients were young females. The disease was bilateral in 90%, affected the axillae and to a lesser extent the pubic and the periareolar areas and rarely the thoracic area, the abdominal area, and the face. FFD followed a relapsing and remitting course, and an evident improvement in disease course was noted after menopause. Conclusion:The typical FFD patient is a post-pubertal female and pre-menopause, presenting with pruritic papules in apocrine-gland-bearing regions. FFD can be sporadic or occurs in family, and it can be asymptomatic in 1/(3-4) of patients and can be triggered by laser hair removal and hormonal changes. Further randomized clinical trials assessing different treatment of FFD are now warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%