Spinning discs with liquid film on the surface have numerous applications in many industrial processes and have attracted a lot of investigations. Centrifugal atomization of metallic melts using a spinning disc is an efficient process for powder production and spray deposition, which is a typical example of a spinning disc interacting with a liquid film. In this paper, the vibration of an atomizing disc excited by a moving melt is analysed and the role of vibration in the disintegration of the melt film on atomizing discs is then investigated. A dynamic model of the atomizing disc as a spinning Kirchhoff plate is established with moving melt film treated as a moving load on the disc and as an unstable growing wave interacting with the surrounding air outside the disc. The powder size is analysed theoretically and then compared with experimental results. It is found that the predicted results agree with the experimental results very well in the film disintegration mode. Furthermore, the influences of the atomizer parameters on the melt break up and powder size are discussed. The control parameters in the centrifugal atomization are identified, which can provide guidance for atomizer designs.