Axonal Patterns of Interneurons in the Cerebral Cortex: In Memory of Rafael Lorente de Nó

Fairén, Alfonso

doi:10.1007/978-1-4615-2932-3_38

Cited by 2 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The horizontal extent in layers II/III of the axonal arbor of type E varied between 350 and 776 m. Because our plane of section was approximately parallel to the rows of barrels (A. Agmon, unpublished observations) and therefore parallel to the minor axis of the barrels, which in mouse is Ͻ200-m-long (Woolsey and Van der Loos, 1970), excitation of type E interneurons would provide inhibition to at least one additional barrel column in the same row, on either or both sides of their own column. Several neurons of all five types, specifically those with cell bodies close to the layers IV/V border, closely resembled the so-called "Lorente de Nó cells" (Cobas et al, 1987;Fairén, 1993) (compare the middle neuron of Fig. 7B to Fig.…”

Section: Several Distinct Morphological Types Of Interneurons Mediatementioning

confidence: 73%

Diverse Types of Interneurons Generate Thalamus-Evoked Feedforward Inhibition in the Mouse Barrel Cortex

Porter¹,

Johnson²,

2001

View full text Add to dashboard Cite

Sensory information, relayed through the thalamus, arrives in the neocortex as excitatory input, but rapidly induces strong disynaptic inhibition that constrains the cortical flow of excitation both spatially and temporally. This feedforward inhibition is generated by intracortical interneurons whose precise identity and properties were not known. To characterize interneurons generating feedforward inhibition, neurons in layers IV and V of mouse somatosensory ("barrel") cortex in vitro were tested in the cell-attached configuration for thalamocortically induced firing and in the whole-cell mode for synaptic responses. Identification as inhibitory or excitatory neurons was based on intrinsic firing patterns and on morphology revealed by intracellular staining. Thalamocortical stimulation evoked action potentials in ϳ60% of inhibitory interneurons but in Ͻ5% of excitatory neurons. The inhibitory interneurons that fired received fivefold larger thalamocortical inputs compared with nonfiring inhibitory or excitatory neurons. Thalamocortically evoked spikes in inhibitory interneurons followed at short latency the onset of excitatory monosynaptic responses in the same cells and slightly preceded the onset of inhibitory responses in nearby neurons, indicating their involvement in disynaptic inhibition. Both nonadapting (fast-spiking) and adapting (regular-spiking) inhibitory interneurons fired on thalamocortical stimulation, as did interneurons expressing parvalbumin, calbindin, or neither calcium-binding protein.Morphological analysis revealed that some interneurons might generate feedforward inhibition within their own layer IV barrel, whereas others may convey inhibition to upper layers, within their own or in adjacent columns. We conclude that feedforward inhibition is generated by diverse classes of interneurons, possibly serving different roles in the processing of incoming sensory information.

show abstract

Section: Several Distinct Morphological Types Of Interneurons Mediatementioning

confidence: 73%

Diverse Types of Interneurons Generate Thalamus-Evoked Feedforward Inhibition in the Mouse Barrel Cortex

Porter¹,

Johnson²,

2001

View full text Add to dashboard Cite

show abstract

“…This paper contains detailed descriptions of many types of neurons based on Golgi staining of what is now known as the primary somatosensory cortex or, more specifically, the barrel field (Fig. A; Kruger and Woolsey, ; Fairén, ; Woolsey, , ; Fairén, ; Larriva‐Sahd, ). These investigations were his debut into this particular field and would culminate in 1938 with the publication of a chapter on cerebral cortex architectonics and structure in John Fulton's treatise on the Physiology of the Nervous System (Lorente de Nó, 1938a).…”

mentioning

confidence: 99%

Lorente de Nó: From Neuroanatomy to Neurophysiology

Espinosa-Sánchez

Espinosa‐Campos

Batuecas‐Caletrío

2019

The Anatomical Record

View full text Add to dashboard Cite

Rafael Lorente de Nó (1902-1990 was the youngest and last of Santiago Ramón y Cajal's students. With Fernando de Castro, Lorente de Nó helped to transition the focus of Ramón y Cajal's School from neuroanatomy to neurophysiology. His main contributions to neuroscience concerned the cytoarchitecture of the cerebral isocortex and hippocampus, neural networks, central vestibular system anatomy, vestibulo-ocular reflex physiology, cochlear nuclei anatomy, and synaptic transmission mechanisms. This article pays tribute to the memory of Lorente de Nó by providing a comprehensive review of the life and work of this giant of neuroscience.

show abstract

Axonal Patterns of Interneurons in the Cerebral Cortex: In Memory of Rafael Lorente de Nó

Cited by 2 publications

References 15 publications

Diverse Types of Interneurons Generate Thalamus-Evoked Feedforward Inhibition in the Mouse Barrel Cortex

Diverse Types of Interneurons Generate Thalamus-Evoked Feedforward Inhibition in the Mouse Barrel Cortex

Lorente de Nó: From Neuroanatomy to Neurophysiology

Contact Info

Product

Resources

About