‘Aye, there's the rub’—Ocular allergy and keratoconus

Liu, Zhengyang; Chong, Elaine

doi:10.1111/ceo.14059

Clinical Exper Ophthalmology

2022

DOI: 10.1111/ceo.14059

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‘Aye, there's the rub’—Ocular allergy and keratoconus

Zhengyang Liu

Elaine Chong

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Cited by 2 publications

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“…Eye rubbing and associated atopic risk factors for KC have received considerable attention in recent years, with 4 systematic reviews and meta-analyses published on this topic since 2020. 5 Seth et al observed significant associations among KC and eye rubbing, family history, and allergy, but not with allergic eye disease, atopy, asthma, and allergic rhinitis. 6 Lo et al found significant associations among KC and eye rubbing, allergic diseases, atopic diseases, asthma, atopic dermatitis/eczema, and allergic eye diseases, but not between KC and allergic rhinitis.…”

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confidence: 98%

Tear Fluid Inflammatory Proteome Analysis Highlights Similarities Between Keratoconus and Allergic Conjunctivitis

Gijs,

Adelaar,

Vergouwen

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose Keratoconus is characterized by the progressive thinning of the cornea, which leads to a cone-like appearance of the eye over time. Although conventionally defined as a noninflammatory condition, a number of recent studies have associated keratoconus (KC) with allergic conjunctivitis (AC) based on clinical parameters. This study aimed to consolidate this association by performing a proteomic analysis of tear fluid from patients with keratoconus and/or allergic conjunctivitis. Methods Of 51 patients, 17 were diagnosed with KC, 17 were diagnosed with AC, and 17 were diagnosed with both KC and AC (combined). Nine of 34 patients with KC had a progressive form of the disease. Tear fluid samples ( n = 51, one eye per patient) were collected by the Schirmer's strips. Tear proteins were extracted from the Schirmer's strips. Proteomic profiling of 384 inflammatory proteins was assessed by a multiplex proximity extension assay (Olink Explore 384 Inflammation Panel I). Results A total of 384 inflammatory proteins were measured. Two hundred seventy-two of the 384 proteins passed stringent data cleaning and were compared among the patient groups. Compared to the 2 other groups, LGALS9 was upregulated uniquely in KC, whereas FGF19, PDGFB, HPCAL1, OSM, and FCAR were downregulated in KC. Similarly, TNFRSF4 and CCL13 were specifically upregulated in AC, whereas ectodysplasin A receptor (EDAR) was uniquely downregulated in AC. Conclusions High-throughput proteomic profiling of tear fluid confirms the association between KC and AC on a molecular level and raise the importance of redefining KC as an inflammatory condition.

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confidence: 98%

Tear Fluid Inflammatory Proteome Analysis Highlights Similarities Between Keratoconus and Allergic Conjunctivitis

Gijs,

Adelaar,

Vergouwen

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Mechanisms of corneal trauma in response to rubbing and other intraocular pressure elevating activities in keratoconus

McMonnies

2022

Expert Review of Ophthalmology

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‘Aye, there's the rub’—Ocular allergy and keratoconus

Cited by 2 publications

References 15 publications

Tear Fluid Inflammatory Proteome Analysis Highlights Similarities Between Keratoconus and Allergic Conjunctivitis

Tear Fluid Inflammatory Proteome Analysis Highlights Similarities Between Keratoconus and Allergic Conjunctivitis

Mechanisms of corneal trauma in response to rubbing and other intraocular pressure elevating activities in keratoconus

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