Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations

Willén, Daniel; Mastio, Roberto; Söderlund, Zackarias; Manner, Sophie; Westergren‐Thorsson, Gunilla; Tykesson, Emil; Ellervik, Ulf

doi:10.1021/acs.bioconjchem.1c00473

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…After being successfully biotinylated using an azide derivative, GAGs obtained from primary fibroblasts stimulated with XylNapN 3 were employed in SPR assays to ascertain the kinetics of their interaction with hepatocyte growth factor. 39…”

Section: Modification Of Gags Applying Click Chemistrymentioning

confidence: 99%

Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications

Bera¹,

Mondal²

2023

SynOpen

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This short review describes the assistance of click chemistry in the chemical modification of glycosaminoglycans. Through an alkyne-azide 1,3-dipolar cycloaddition reaction, the chemically and physiologically stable triazole unit connects glycosaminoglycans with other labelled or attached functionalities. The synthesized glycosaminoglycan (GAG) conjugates act as drug carriers, forming hydrogels or nanohydrogels for localized drug delivery or injectable GAGs and so on. These are used in research on antithrombotic agents, protein binding, and hepatocyte growth factors, as well as in mechanistic studies of glycosaminoglycans biosynthesis and wound healing.1 Introduction2 Synthetic Modification of GAGS3 Click Chemistry4 Modification of GAGS Applying Click Chemistry5 Conclusions6 Abbreviations

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Section: Modification Of Gags Applying Click Chemistrymentioning

confidence: 99%

Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications

Bera¹,

Mondal²

2023

SynOpen

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Hybrid emulsifier systems: Alkyl imidazolium lactoside surfactants derived from natural resources

Salman

2022

Carbohydrate Research

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Excavating proteoglycan structure-function relationships: modern approaches to capture the interactions of ancient biomolecules

Critcher

Huang

2022

American Journal of Physiology-Cell Physiology

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Proteoglycans are now well regarded as key facilitators of cell biology. While a majority of their interactions and functions are attributed to the decorating glycosaminoglycan chains, there is a growing appreciation for the roles of the proteoglycan core protein and for considering proteoglycans as replete protein-glycan conjugates. This appreciation, seeded by early work in proteoglycan biology, is now being advanced and exalted by modern approaches in chemical glycobiology. In this review, we discuss up-and-coming methods to unearth the fine-scale architecture of proteoglycans that modulate their functions and interactions. Crucial to these efforts is the production of chemically defined materials, including semi-synthetic proteoglycans and the in situ capture of interacting proteins. Together, the integration of chemical biology approaches promises to expedite the dissection of the structural heterogeneity of proteoglycans and deliver refined insight into their functions.

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Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations

Cited by 3 publications

References 29 publications

Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications

Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications

Hybrid emulsifier systems: Alkyl imidazolium lactoside surfactants derived from natural resources

Excavating proteoglycan structure-function relationships: modern approaches to capture the interactions of ancient biomolecules

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