Azithromycin

Bakheit, Ahmed H.; Al-Hadiya, Badraddin M.H.; Abdelgalil, Ahmed A.

doi:10.1016/b978-0-12-800173-8.00001-5

Cited by 103 publications

(69 citation statements)

References 49 publications

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“…1 Azithromycin is a macrolide antibiotic and is used in lower respiratory infections and skin infections. 2 In this report, we present a patient who developed FDE after using azithromycin for acute tonsillitis.…”

Section: Fixed Drug Eruption Probably Induced By Azithromycinmentioning

confidence: 97%

“…1 EVHC occurring at atypical sites are reported, including the face and vulva. 2,3 A 45-year old Sri Lankan woman presented to a dermatology outpatient clinic with a 6-month history of vulval lesions. She reported hair removal via shaving this area for many years.…”

Section: Eruptive Vellus Hair Cysts Of the Vulvamentioning

confidence: 99%

“…

Siegel adverse drug reaction severity assessment scale (level 3).Azithromycin is considered a safe drug despite its numerous side-effects. 2 In the literature only one case of FDE induced by azithromycin has been reported. 4 Although FDE caused by azithromycin is likely rare clinicians should be aware of this possibility.

…”

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confidence: 99%

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Fixed drug eruption probably induced by azithromycin

Demir

Akdeniz

2017

Aust J Dermatology

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Plant products for practising procedural dermatologyProcedures form an inextricable part of the dermatologist's practice. When first undertaking a new procedure, novices are often daunted by the steep learning curve in the first few months, an experience we (the authors) empathise with. The use of fruit and vegetables may lessen some of the stress and enhance a sense of fulfilment in the nascent proceduralist. Bananas, the most popular fruit in the Western world, provide a readily available curved surface with intrinsic layers on which newly appointed registrars can practise suturing. Mohs fellows can practise removing surgical 'debulks' and taking bevelled, uniformly thin Mohs layers, 1 an initially alien concept to the recently graduated dermatology registrar that will become increasingly familiar during their training. For the new laser practitioner, aubergines provide a ready source of water-rich material that provides an ideal medium on which to practise ablative laser surgery, including with devices such as the carbon dioxide laser. The purple skin of the aubergine provides a clearly visible surface that can be ablated and give an indication of the depth of penetration and the extent of fractionation. Furthermore, aubergines do not tend to explode on being vaporisedan important, pragmatic advantage of this vegetable. Plant-procured products can provide a cheap, accessible, less pungent alternative to porcine skin and synthetic models and can hugely improve the experience of procedural dermatologists. We suggest those learning new procedures (and their trainers) consider these tools to augment their learning.

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Section: Fixed Drug Eruption Probably Induced By Azithromycinmentioning

confidence: 97%

Section: Eruptive Vellus Hair Cysts Of the Vulvamentioning

confidence: 99%

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Fixed drug eruption probably induced by azithromycin

Demir

Akdeniz

2017

Aust J Dermatology

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“…Macrolides stop bacterial growth by inhibiting protein synthesis [17]. Through reversibly binding to the 50S subunit of the 70S bacterial ribosomes, macrolides block further translation of proteins [17].…”

Section: Pharmacodynamicsmentioning

confidence: 99%

“…Through reversibly binding to the 50S subunit of the 70S bacterial ribosomes, macrolides block further translation of proteins [17]. As a result, macrolides are effective against actively dividing organisms.…”

Section: Pharmacodynamicsmentioning

confidence: 99%

PharmGKB summary

Fohner

Sparreboom

Altman

et al. 2017

Pharmacogenetics and Genomics

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Nitazoxanide and azithromycin for the early treatment of COVID‐19: A multi‐spectroscopic, biochemical and computational drug–drug interaction study

Ali

Abid

Ahmed

et al. 2023

J Chinese Chemical Soc

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Herein, we present an experimental and theoretical drug-drug interaction study between nitazoxanide (NTZ) and azithromycin (AZT) in an aqueous solution. Interaction was studied by using UV/Vis, fluorescence, attenuated total reflectance-fourier transform infrared (ATR-FTIR), and circular dichroism (CD) spectroscopy, while molecular docking studies were performed to establish the interaction computationally. A bright yellow color was observed when the two drugs interacted, giving a hyperchromic band at 420 nm. The rate of absorbance was linearly increased by increasing drug concentrations and in a time-dependent manner. Stability of the interaction complex (i.e., NTZ: AZT) was measured at variable temperatures (25-80 C), pH (5.0-10.0) and ionic strength (0.05-2.0 M NaCl), and not only proved stable but also retained antimicrobial potential with reduced cellular toxicity. Mole ratio and Job's method of continuous variations were used to establish the binding stoichiometry and found to be 2:1. The calculated binding constant (k b = 8,400 M À1 ) and Gibb's free energy (ΔG = À22.4 KJ/mol) also suggested an energetically favorable interaction. FTIR spectra of NTZ: AZT complex in comparison with two drugs alone revealed significant interaction which was nicely complemented by molecular docking studies. Interaction was also successfully demonstrated in presence of carrier protein HSA and by spiking the two drugs in real samples of human plasma and urine.

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Azithromycin

Cited by 103 publications

References 49 publications

Fixed drug eruption probably induced by azithromycin

Fixed drug eruption probably induced by azithromycin

PharmGKB summary

Nitazoxanide and azithromycin for the early treatment of COVID‐19: A multi‐spectroscopic, biochemical and computational drug–drug interaction study

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