Azithromycin Treatment for SARS-CoV-2-related COVID-19 Pandemic Could Worsen Extensively Drug Resistant (XDR) Typhoid: A Risk of Losing the Last Bullet Against Salmonella enterica Serovar Typhi

Saeed, Umar; Uppal, Sara Rizwan; Piracha, Zahra Zahid; Uppal, Rizwan

doi:10.5812/jjm.113874

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…The rising burden of cutaneous fungal infections has been a persistently neglected public health problem for decades. This phenomenon remained more pronounced during the global surge of COVID-19 cases when physicians and scientists across the globe were focused on identifying ways to treat or cure SARS-CoV-2 infections [6][7][8][9][10][11][12][13]. The current study is the torchbearer for strategic organizations to develop measures to prevent the future spread of cutaneous fungal infections not only the urban areas but also in rural areas across the globe.…”

Section: Discussionmentioning

confidence: 99%

Dermatomycoses in Pakistan; an urgent need for National Surveillance Programs

Rizwan¹,

Ahmad²,

Saeed³

et al. 2022

Ann Dermatol Res

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Despite the rising burden of fungal infections across the globe, the World Health Organization's efforts remained questionable in fungal infection-related projects. Most of the developing countries consequently lost focus on the need for assessment and establishment of national surveillance set up or advanced technology hubs against mycological infections. The current study aimed to the determination of the local burden of cutaneous fungal infections in 2019-2021. Among 497 suspected fungal cultures, 22.5% depicted fungal growth. Among males, the prevalence of dermatomycosis was 0.75 times higher than in females. Penicillium species followed by Epidermophyton and Candida species were common among subjects of < 30 years of age. The Aspergillus spp, Penicillium spp, mucormycosis agents, and Candida albicans infections were more common among subjects 30 to 60 years of age. Aspergillus species were more commonly observed among patients > 60 of age. 22.2% of the fungal infections were Penicillium species, 9% of the infections were Aspergillus species, followed by 4.4% of Epidermophyton, mucormycosis, Candida species, and Candida albicans respectively. There is an urgent need for the establishment of national policy for the prevention of fungal disease.

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Section: Discussionmentioning

confidence: 99%

Dermatomycoses in Pakistan; an urgent need for National Surveillance Programs

Rizwan¹,

Ahmad²,

Saeed³

et al. 2022

Ann Dermatol Res

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“…After several reports of resistant isolates with MICs ≥32 µg/ml and clinical failure with azithromycin, it is feared that we may soon run out of this option. Several publications and editorials have raised concerns of increased azithromycin resistance due to its unjudicial use as a broad spectrum respiratory antimicrobial after the COVID-19 pandemic [15,20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, owing to large-scale empirical use of azithromycin after the COVID-19 pandemic, there are concerns about its rising resistance and it is feared that we may soon run out of treatment options for XDR typhoid [15].…”

Section: Introductionmentioning

confidence: 99%

Disc Diffusion Testing of Azithromycin Against Clinical Isolates of Typhoidal Salmonellae: A Diagnostic Conundrum

Shoaib¹,

Satti²,

Hussain³

et al. 2021

Cureus

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Introduction: Typhoid remains a major healthcare problem in low and middle-income countries. The emergence of extremely drug-resistant (XDR) typhoid strains from the Indian subcontinent has led to very limited therapeutic options. Azithromycin being the only oral option for XDR typhoid faces a threat of rapid resistance due to its overuse after the COVID-19 pandemic.Objective: To evaluate the reliability of azithromycin disc diffusion testing against clinical isolates of typhoidal salmonellae in comparison with E-test minimum inhibitory concentrations (MICs).Study design: This is a cross-sectional validation study.

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“…The prevalence of viral infections is unfortunately increasing day by day due to the limited awareness among general population (9)(10)(11)(12). Poor diagnostic abilities and inadequate knowledge about viral transmission via fomites limit accurate acquisition of prevalence rates (13,14).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Epidemic Prevention Abilities for Severe Acute Respiratory Syndrome Coronavirus-2 and Middle East Respiratory Syndrome Coronavirus in South Korea

Saeed¹,

Piracha²,

Uppal³

et al. 2021

Jundishapur J Microbiol

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: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) preferentially infects respiratory tract cells, but it has organotropism. Middle East respiratory syndrome coronavirus (MERS-CoV) is significantly distinct from common cold and SARS coronavirus. In past few years, the SARS-CoV-2 and MERS-CoV caused several deaths in South Korea. The aim of current study was to assess SARS-CoV-2 and MERS-CoV awareness and epidemic prevention ability in South Koreans.According to our results, out of 1500 participants, 98.8% and 64.3% were aware of SARS-CoV-2 and MERS-CoV, respectively. Moreover, 97% of the participants used masks for prevention of airborne diseases, while 65.3% of the participants reused the same mask for several days. In addition, 50% of the participants were not satisfied with the government support. Future viral epidemics can be prevented by disseminating advanced knowledge and awareness among general public.

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Azithromycin Treatment for SARS-CoV-2-related COVID-19 Pandemic Could Worsen Extensively Drug Resistant (XDR) Typhoid: A Risk of Losing the Last Bullet Against Salmonella enterica Serovar Typhi

Cited by 11 publications

References 9 publications

Dermatomycoses in Pakistan; an urgent need for National Surveillance Programs

Dermatomycoses in Pakistan; an urgent need for National Surveillance Programs

Disc Diffusion Testing of Azithromycin Against Clinical Isolates of Typhoidal Salmonellae: A Diagnostic Conundrum

Evaluation of Epidemic Prevention Abilities for Severe Acute Respiratory Syndrome Coronavirus-2 and Middle East Respiratory Syndrome Coronavirus in South Korea

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