Azithromycin Versus Doxycycline for Genital Chlamydial Infections

Abstract

Azithromycin and doxycycline are equally efficacious in achieving microbial cure and have similar tolerability. Further head-to-head trials comparing these antibiotics are unnecessary.

Prevalence of Malaria and Sexually Transmitted and Reproductive Tract Infections in Pregnancy in Sub-Saharan Africa

“…61 A single 2-g dose of azithromycin was 98.9% (95% CI, 97.9%-100%) efficacious against N gonorrhoeae in the United States, 62 while meta-analysis showed that 1 g cures 96.5% (95% CI, 95.3%-97.7%) of C trachomatis infections. 63 A trial in Malawi using 1 g of azithromycinadministeredtwicewithSPIPTp reduced the risk of T vaginalis 35% (P=.02). 64 Azithromycin-basedcombinations could protect against bacterial vaginosis if administered early in pregnancy; a meta-analysis of antibiotic therapy for thetreatmentofbacterialvaginosisinpregnancy prior to gestational week 20 is associatedwithasignificantreductioninthe risk of preterm birth.…”

The Role of Chlamydia trachomatis in Male Infertility

“…Each antibiotic regimen has advantages or disadvantages in terms of cost, convenience, and compliance, yet both regimens will remain www.intechopen.com recommended as first-line therapy for uncomplicated chlamydial infection in nonpregnant individuals [140]. However, in patients who have erratic health-care-seeking behavior, poor treatment compliance, or unpredictable follow-up, azithromycin might be more costeffective in treating chlamydia because it enables the provision of a single-dose of directly observed therapy [139,141].…”

Chlamydia trachomatis Infection and Reproductive Health Outcomes in Women

“…Both regimens have shown an efficacy of >95% in the microbial cure of C. trachomatis (54), although compliance is lower with doxycycline. A single dose of azithromycin should be the treatment of choice in persons who may not be able to comply with longer treatment regimens.…”