2022
DOI: 10.3390/antibiotics11101375
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Azole-Based Compounds That Are Active against Candida Biofilm: In Vitro, In Vivo and In Silico Studies

Abstract: Fungal pathogens, including Candida spp., Aspergillus spp. and dermatophytes, cause more than a billion human infections every year. A large library of imidazole- and triazole-based compounds were in vitro screened for their antifungal activity against C. albicans, C. glabrata, C. krusei, A. fumigatus and dermatophytes, such as Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes. The imidazole carbamate 12 emerged as the most active compound, showing a valuable antifungal activity against … Show more

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Cited by 9 publications
(6 citation statements)
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“…The simulation was run, with a time step of 2.5 fs and using the RESPA integrator. The interactions between the ligand and protein during the binding were analyzed, as well as the RMSD, of the Cα atoms of the protein and the heavy atoms of the ligand, by utilizing Desmond [52,53] …”
Section: Methodsmentioning
confidence: 99%
“…The simulation was run, with a time step of 2.5 fs and using the RESPA integrator. The interactions between the ligand and protein during the binding were analyzed, as well as the RMSD, of the Cα atoms of the protein and the heavy atoms of the ligand, by utilizing Desmond [52,53] …”
Section: Methodsmentioning
confidence: 99%
“…The interactions between the ligand and protein during the binding were analyzed, as well as the RMSD, of the Cα atoms of the protein and the heavy atoms of the ligand, by utilizing Desmond. [35][36][37][38]…”
Section: Molecular Dynamics Simulationsmentioning
confidence: 99%
“…While current therapeutic options for IFIs are limited to only three classes of drugs (i.e., polyenes, azoles and echinocandins), the emergence of resistant strains to some of these molecules is even more concerning. For decades, azoles have been the most frequently used antifungal for treating Candida infections ( Sheehan et al., 1999 ; Carradori et al., 2022 ). Although treatment with azoles can be effective, long-term use of fluconazole (FLC) has led to the emergence of Candida strains with decreased susceptibility.…”
Section: Introductionmentioning
confidence: 99%