Azole Resistance in Candida Species Isolated from Diabetic Women with Vulvovaginal Candidiasis in a Tertiary Care Centre

Paul, LM; Rejitha, I.M.; Revathy, C.

doi:10.20546/ijcmas.2019.802.085

Cited by 2 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, 4.6% of all Candida strains (C. albicans: 4% and C. glabrata: 6.5%) were resistant to ITC. Resistance to ITR was detected in the previous studies (20,32,34,35), and in contrast, some researchers did not observe any resistance to ITC (36). In the study conducted by Gross et al in Costa Rica, 100% of C. albicans isolates were susceptible to ITC (37).…”

Section: Discussionmentioning

confidence: 82%

Azole Antifungal Resistance in Candida albicans and Candida glabrata Isolated from Vulvovaginal Candidiasis Patients

Deravi

Fathi

Tabatabaeifar

et al. 2021

Arch Clin Infect Dis

View full text Add to dashboard Cite

Background: Vulvovaginal candidiasis (VVC) is the most frequent fungal disorder in healthy and normal women. Objectives: The aim of this study was to evaluate the in vitro antifungal susceptibility of clinical isolates Candida albicans and Candida glabrata, the two most common candida species in Iranian patients with VVC. Methods: One hundred and eight clinical isolates of candida, including; C. albicans (n = 77) and C. glabrata: (n = 31) were isolated from the 108 patients with VVC. The in vitro activity of caspofungin (CAS), amphotericin B (AMB), voriconazole (VRC), itraconazole (ITC), fluconazole (FLC), and nystatin (NYS) were determined according to the CLSI M27-A3 and CLSI M27-S4. Results: Our results were shown 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4%, and 3.7% of all isolates, and six isolates (5.6%) had intermediate MIC to CAS. Conclusions: We reported 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4% and 3.7% of all isolates, respectively.

show abstract

Section: Discussionmentioning

confidence: 82%

Azole Antifungal Resistance in Candida albicans and Candida glabrata Isolated from Vulvovaginal Candidiasis Patients

Deravi

Fathi

Tabatabaeifar

et al. 2021

Arch Clin Infect Dis

View full text Add to dashboard Cite

show abstract

“…In vitro analysis of antifungal activity of antifungal agents enables comparison between different antimycotics, which in turn may clarify the reasons for lack of clinical response and assist clinicians in choosing an effective therapy for their patients. However, it is important that the methodologies used for in vitro testing be standardized to facilitate the establishment of quality control parameters and interpretive breakpoints [17] .…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported documented cases of terbinafineresistant T. rubrum [23,24]. The least active agent was ketoconazole with MIC ranges of 0.875- [17] , although the use of agar dilution method for dermatophytes susceptibility testing is much sufficient. Most studies have showed that agar dilution seems to be an alternative method to MIC-determination of antifungal drugs for dermatophytes, especially in underdeveloped countries, though it is a laborious methodology, but results could be obtained faster and more cost-effectively [25] .…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antifungal Susceptibility Profiles of Dermatophytes Isolates from Tinea Capitis in Northwest, Nigeria

Ungo-kore

Ehinmidu

Onaolapo

et al. 2021

IEM

View full text Add to dashboard Cite

Background:The fungal infection of tinea capitis is a common mycosis that affects the scalp superficially, especially in children. Oral treatment of this infection remains the preferred treatment process in clinical dermatology. Many antifungals available for dermatophyte treatment lead to treatment failure. Determination of antifungal susceptibility of dermatophytes in-vitro has been reported to be important to curb dermatophyte infections using effective antifungal drugs. The aim of this study was to investigate and determine in vitro minimum inhibitory concentration (MIC) of amphotericin B, ketoconazole, griseofulvin, terbinafine, and fluconazole against dermatophyte clinical isolates using agar dilution method. Materials and Methods: In this study, in vitro susceptibilities of 32 dermatophyte clinical isolates collected from primary school pupils in Sokoto metropolis were investigated to five antifungals (fluconazole, terbinafine, ketoconzole, amphotericin B, and griseofulvin) using the CLSI agar dilution method. Findings: The results obtained revealed that griseofulvin and terbinafine were the most potent antifungal agents among those tested. Conclusion: Agar dilution method could be an alternative method for MIC-determination of antifungal drugs against dermatophyte species, since it is cost effective and affordable with consistent results, especially in developing countries.

show abstract

Azole Resistance in Candida Species Isolated from Diabetic Women with Vulvovaginal Candidiasis in a Tertiary Care Centre

Cited by 2 publications

References 9 publications

Azole Antifungal Resistance in Candida albicans and Candida glabrata Isolated from Vulvovaginal Candidiasis Patients

Azole Antifungal Resistance in Candida albicans and Candida glabrata Isolated from Vulvovaginal Candidiasis Patients

In Vitro Antifungal Susceptibility Profiles of Dermatophytes Isolates from Tinea Capitis in Northwest, Nigeria

Contact Info

Product

Resources

About