Azone® Decreases the Buccal Mucosal Permeation of Diazepam in a Concentration-Dependent Manner via a Reservoir Effect

Meng-Lund, Emil; Jacobsen, Jette Bredahl; Jin, Liang; Janfelt, Christian; Holm, René; Müllertz, Anette; Nicolazzo, Joseph A.

doi:10.1002/jps.23877

Cited by 12 publications

(1 citation statement)

References 34 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relatively poor recovery for propranolol is likely due to adsorption to the Ussing chamber walls and cell inserts. It has previously been shown that diazepam, a lipophilic small molecule, adsorbed to Ussing chamber walls during transport studies [44]. In the cell studies the recovery was initially measured without adding propranolol content in the filter-grown cells, as these were used in viability testing; however, the recovery of propranolol was only 56.5% (Table 4).…”

Section: Total Drug Recoverymentioning

confidence: 99%

Mucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules

Marxen

Mosgaard

Pedersen

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

Self Cite

View full text Add to dashboard Cite

 Users may download and print one copy of any publication from the public portal for the purpose of private study or research.  You may not further distribute the material or use it for any profit-making activity or commercial gain  You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

show abstract

Section: Total Drug Recoverymentioning

confidence: 99%