Mucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules

Abstract

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Buccal Bullfrog (Rana catesbeiana Shaw) Oil Emulsion: A Mucoadhesive System Intended for Treatment of Oral Candidiasis

“…The epithelium surface of the buccal mucosa is covered by a mucus layer responsible for its lubrication, protection, and hydration. This layer is composed by a viscoelastic network of water (95%) and mucin (5%), a glycoprotein responsible for the viscosity and gel properties of the mucus [26,43]. Thus, many studies have evaluated the interaction between dispersed systems and this glycoprotein with the purpose of predicting the mucoadhesion ability of these systems, which is related to increased interactions with the buccal mucosa and site-specific delivery of drugs and/or bioactive compounds [26,44].…”

Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

“…62 The cell viability during the permeation studies was indicated by the recorded TEER values, which are in close agreement with previous reports. 40,63 Contrariwise, the viability studies were conducted after the application of pre-dissolved film fractions. The treatment of the TR146 cell line with the fabricated formulations exhibited satisfactory viability of the epithelial cells, even for the maximum dosing profiles.…”

A mussel-inspired film for adhesion of wet buccal tissue and efficient buccal drug delivery

“…6c). In addition, an in vitro monolayer model including a mucus layer was developed 47,48 . The TR146 cells was adopted as cell model because they could form an epithelium resembling that of non-keratinized buccal mucosa 49 .…”

“…The TR146 cells was adopted as cell model because they could form an epithelium resembling that of non-keratinized buccal mucosa 49 . A mucus layer was deposited onto the TR146 cell monolayers 47,48 . The TR146 cell monolayer model treated with PLGA-PDA NPs were found most obvious in fluorescent intensity ( Fig.…”